 |
|
| RTECS Number |
KQ6300000 |
| Chemical Name |
Ethyl alcohol |
| CAS Registry Number |
64-17-5 |
| Last Updated |
201204 |
| Data Items Cited |
856 |
| Molecular Formula |
C2-H6-O |
| Molecular Weight |
46.08 |
| Wiswesser Line Notation |
Q2 |
| Compound Descriptor |
Tumorigen
Drug
Mutagen
Natural Product
Human
Primary Irritant
Reproductive Effector |
- Synonyms/Trade Names
- Absolute ethanol
Aethanol
Aethylalkohol
Alcohol
Alcohol dehydrated
Alcohol, anhydrous
Alcool ethylique
Alcool etilico
Algrain
Alkohol
Alkoholu etylowego
Anhydrol
Cologne Spirit
Etanolo
Ethanol
Ethanol
Ethyl alcohol
Ethyl alcohol anhydrous
Ethyl hydrate
Ethyl hydroxide
Etylowy alkohol
Fermentation alcohol
Grain alcohol
Jaysol
Jaysol S
Methylcarbinol
Molasses alcohol
NCI-C03134
Potato alcohol
SD alcohol 23-hydrogen
Spirits of wine
Spirt
Tecsol
|
| Type of Test |
Route of Exposure or Administration |
Species/Test System |
Dose Data |
Reaction Severity |
Reference |
|
Open irritation test
|
Administration onto the skin
|
Rodent - rabbit
|
400 mg
|
Mild
|
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/22/1970
|
|
Standard Draize test
|
Administration onto the skin
|
Rodent - rabbit
|
20 mg/24H
|
Moderate
|
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,189,1986
|
|
Standard Draize test
|
Administration into the eye
|
Rodent - rabbit
|
500 mg
|
Severe
|
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946
|
|
Standard Draize test
|
Administration into the eye
|
Rodent - rabbit
|
500 mg/24H
|
Mild
|
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,189,1986
|
|
Rinsed with water
|
Administration into the eye
|
Rodent - rabbit
|
100 mg/4S
|
Moderate
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982
|
|
Standard Draize test
|
Administration into the eye
|
Rodent - rabbit
|
100 uL
|
Moderate
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
Standard Draize test
|
Administration onto the skin
|
Human
|
70%/2D
|
|
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975- Volume(issue)/page/year: 61,163,2009
|
|
| Type of Test |
Route of Exposure or Administration |
Species/Test System |
Dose Data |
Toxic Effects |
Reference |
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
22500 mg/kg/4W (intermittent)
|
Endocrine - other changes
Blood - other changes
|
CLECAP Clinical Endocrinology (Oxford). (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1972- Volume(issue)/page/year: 25,143,1986
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - infant
|
11712 uL/kg
|
Behavioral - general anesthetic
Cardiac - arrhythmias (including changes in conduction)
Lungs, Thorax, or Respiration - dyspnea
|
JOUOD4 Journal of UOEH (University of Occupational and Environmental Health). (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807, Japan) V.1- 1979- Volume(issue)/page/year: 9,53,1987
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - woman
|
1200 mg/kg/3H
|
Endocrine - changess in gonadotropins
Endocrine - other changes
Blood - other changes
|
ACRSDM Alcoholism: Clinical and Experimental Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1977- Volume(issue)/page/year: 7,289,1983
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
3371 uL/kg
|
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - excitement
Behavioral - coma
|
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 21,272,1979
|
|
LDLo - Lowest published lethal dose
|
Oral
|
Human - child
|
2 gm/kg
|
Lungs, Thorax, or Respiration - other changes
Liver - fatty liver degeneration
Blood - other changes
|
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 17,183,1958
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - child
|
14400 mg/kg/30M (intermittent)
|
Behavioral - coma
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - nausea or vomiting
|
APSVAM Acta Paediatrica Scandinavica. (Almqvist & Wiksell International, POB 4627, S-11691 Stockholm, Sweden) V.54-80 1965-91 For publisher information, see APAEEL Volume(issue)/page/year: 74,977,1985
|
|
LDLo - Lowest published lethal dose
|
Oral
|
Human
|
1400 mg/kg
|
Behavioral - sleep
Behavioral - headache
Gastrointestinal - nausea or vomiting
|
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,44,1974
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
50 mg/kg
|
Gastrointestinal - alteration in gastric secretion
Gastrointestinal - other changes
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 56,117,1936
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
1430 ug/kg
|
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Behavioral - antipsychotic
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 197,488,1976
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - woman
|
256 gm/kg/12W
|
Behavioral - hallucinations, distorted perceptions
Endocrine - effect on menstrual cycle
|
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 238,2143,1977
|
|
LDLo - Lowest published lethal dose
|
Subcutaneous
|
Human - infant
|
19440 mg/kg
|
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
Nutritional and Gross Metabolic - body temperature decrease
|
AJCPAI American Journal of Clinical Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1931- Volume(issue)/page/year: 5,466,1935
|
|
LD50 - Lethal dose, 50 percent kill
|
Oral
|
Rodent - rat
|
7060 mg/kg
|
Lungs, Thorax, or Respiration - other changes
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,718,1970
|
|
LC50 - Lethal concentration, 50 percent kill
|
Inhalation
|
Rodent - rat
|
20000 ppm/10H
|
Details of toxic effects not reported other than lethal dose value
|
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,44,1974
|
|
LD50 - Lethal dose, 50 percent kill
|
Intraperitoneal
|
Rodent - rat
|
3600 ug/kg
|
Details of toxic effects not reported other than lethal dose value
|
PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 2,27,1969
|
|
LD50 - Lethal dose, 50 percent kill
|
Intravenous
|
Rodent - rat
|
1440 mg/kg
|
Lungs, Thorax, or Respiration - dyspnea
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,60,1971
|
|
LD50 - Lethal dose, 50 percent kill
|
Intraarterial
|
Rodent - rat
|
11 mg/kg
|
Lungs, Thorax, or Respiration - chronic pulmonary edema
Lungs, Thorax, or Respiration - dyspnea
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,60,1971
|
|
LD50 - Lethal dose, 50 percent kill
|
Oral
|
Rodent - mouse
|
3450 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(3),31,1967
|
|
LD50 - Lethal dose, 50 percent kill
|
Intraperitoneal
|
Rodent - mouse
|
528 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
STRAAA Strahlentherapie. (Urban & Schwarzenberg, Postfach 202440, D-8000 Munich 2, Fed. Rep. Ger.) V.1- 1912- Volume(issue)/page/year: 127,245,1965
|
|
LD50 - Lethal dose, 50 percent kill
|
Subcutaneous
|
Rodent - mouse
|
8285 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 48A,99,1970
|
|
LDLo - Lowest published lethal dose
|
Intraperitoneal
|
Mammal - dog
|
3 gm/kg
|
Details of toxic effects not reported other than lethal dose value
|
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 1,207,1944
|
|
LDLo - Lowest published lethal dose
|
Subcutaneous
|
Mammal - dog
|
6 gm/kg
|
Details of toxic effects not reported other than lethal dose value
|
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 1,130,1955
|
|
LDLo - Lowest published lethal dose
|
Intravenous
|
Mammal - dog
|
1600 mg/kg
|
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - hypermotility, diarrhea
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,60,1971
|
|
LDLo - Lowest published lethal dose
|
Oral
|
Mammal - cat
|
6 gm/kg
|
Gastrointestinal - gastritis
Liver - hepatitis (hepatocellular necrosis), diffuse
Kidney/Ureter/Bladder - interstitial nephritis
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 56,117,1936
|
|
LDLo - Lowest published lethal dose
|
Intravenous
|
Mammal - cat
|
3945 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 1,130,1955
|
|
LD50 - Lethal dose, 50 percent kill
|
Intraperitoneal
|
Rodent - rabbit
|
963 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985
|
|
LDLo - Lowest published lethal dose
|
Subcutaneous
|
Rodent - rabbit
|
20 gm/kg
|
Details of toxic effects not reported other than lethal dose value
|
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,651,1980
|
|
LD50 - Lethal dose, 50 percent kill
|
Intravenous
|
Rodent - rabbit
|
2374 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985
|
|
LCLo - Lowest published lethal concentration
|
Inhalation
|
Rodent - guinea pig
|
21900 ppm
|
Details of toxic effects not reported other than lethal dose value
|
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 48A,99,1970
|
|
LD50 - Lethal dose, 50 percent kill
|
Intraperitoneal
|
Rodent - guinea pig
|
3414 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985
|
|
LD50 - Lethal dose, 50 percent kill
|
Intraperitoneal
|
Rodent - hamster
|
5068 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985
|
|
LDLo - Lowest published lethal dose
|
Subcutaneous
|
Bird - pigeon
|
5 gm/kg
|
Details of toxic effects not reported other than lethal dose value
|
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
|
|
LDLo - Lowest published lethal dose
|
Subcutaneous
|
Bird - chicken
|
5 gm/kg
|
Details of toxic effects not reported other than lethal dose value
|
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
|
|
LDLo - Lowest published lethal dose
|
Intravenous
|
Bird - chicken
|
8216 mg/kg
|
Vascular - other changes
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 60,312,1937
|
|
LDLo - Lowest published lethal dose
|
Subcutaneous
|
Amphibian - frog
|
7100 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 1,128,1955
|
|
LDLo - Lowest published lethal dose
|
Parenteral
|
Amphibian - frog
|
36 gm/kg
|
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change
Behavioral - somnolence (general depressed activity)
|
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 50,296,1935
|
|
LD50 - Lethal dose, 50 percent kill
|
Intraperitoneal
|
Mammal - species unspecified
|
4300 mg/kg
|
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 13,358,1968
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
6.4 gm/kg
|
Gastrointestinal - alteration in gastric secretion
Gastrointestinal - ulceration or bleeding from stomach
|
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 70,17,2001
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
4.2 gm/kg
|
Nutritional and Gross Metabolic - body temperature decrease
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 293,188,2000
|
|
LCLo - Lowest published lethal concentration
|
Inhalation
|
Rodent - mouse
|
117000 mg/m3/2H
|
Details of toxic effects not reported other than lethal dose value
|
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - mouse
|
50000 mg/m3/2H
|
Behavioral - alteration of classical conditioning
|
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - mouse
|
2500 mg/m3/40M
|
Brain and Coverings - other degenerative changes
|
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1500 mg/kg
|
Behavioral - ataxia
|
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
12000 mg/m3/8H
|
Behavioral - general anesthetic
|
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - guinea pig
|
12000 mg/m3/8H
|
Behavioral - general anesthetic
|
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rabbit
|
2500 mg/m3/40M
|
Brain and Coverings - other degenerative changes
|
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Human
|
2500 mg/m3/20M
|
Peripheral Nerve and Sensation - recording from afferent nerve
|
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
2.45 gm/kg
|
Behavioral - altered sleep time (including change in righting reflex)
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 299,698,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
2.5 gm/kg
|
Gastrointestinal - other changes
|
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 365,17,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
5 gm/kg
|
Brain and Coverings - other degenerative changes
Vascular - other changes
Liver - other changes
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 298,737,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
8000 mg/kg
|
Brain and Coverings - other degenerative changes
Cardiac - cardiomyopathy including infarction
Liver - multiple effects
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 50,52,1987
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
3 gm/kg
|
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 44,319,1981
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
5 gm/kg
|
Behavioral - changes in motor activity (specific assay)
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 44,319,1981
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
3500 mg/kg
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 51,92,1988
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
6000 mg/kg
|
Biochemical - Metabolism (Intermediary) - effect on mitochondrial function
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 55,18,1992
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Human
|
1.6 gm/kg/6H
|
Biochemical - Metabolism (Intermediary) - other
|
CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960- Volume(issue)/page/year: 67,591,2000
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
4800 mg/kg
|
Gastrointestinal - ulceration or bleeding from stomach
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 51,82,1988
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
1000 mg/kg
|
Brain and Coverings - other degenerative changes
Liver - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
|
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 59,38,1996
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
10 mL/kg
|
Gastrointestinal - gastritis
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 303,1301,2002
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - mouse
|
3 gm/kg
|
Behavioral - sleep
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 302,257,2002
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - mouse
|
3 gm/kg
|
Behavioral - sleep
Behavioral - tolerance
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 302,257,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
5 gm/kg
|
Blood - other changes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,99,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Bird - pigeon
|
1 gm/kg
|
Behavioral - changes in psychophysiological tests
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 293,551,2000
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
5 mL/kg
|
Gastrointestinal - alteration in gastric secretion
Gastrointestinal - ulceration or bleeding from stomach
|
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 16,311,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
5 gm/kg
|
Liver - changes in liver weight
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,98,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Primate - monkey
|
4.8 mg/kg
|
Behavioral - abuse
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 301,993,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
1 gm/kg
|
Behavioral - changes in motor activity (specific assay)
Behavioral - aggression
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 157,131,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
6 gm/kg
|
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,202,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - woman
|
0.7 gm/kg
|
Behavioral - changes in psychophysiological tests
|
JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987- Volume(issue)/page/year: 16,379,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
5.25 gm/kg
|
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,128,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
4 gm/kg
|
Endocrine - other changes
Blood - changes in spleen
Immunological Including Allergic - decrease in cellular immune response
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,172,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
0.5 gm/kg
|
Behavioral - changes in psychophysiological tests
|
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 462,115,2003
|
|
TDLo - Lowest published toxic dose
|
Intramuscular
|
Non-mammalian species
|
0.1 gm/kg
|
Cardiac - other changes
Musculoskeletal - other changes
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 542,1,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1600 mg/kg
|
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - lipids including transport
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 41,1551,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
0.8 gm/kg
|
Behavioral - euphoria
Behavioral - somnolence (general depressed activity)
Behavioral - changes in psychophysiological tests
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 300,236,2002
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
1.75 gm/kg
|
Behavioral - ataxia
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 153,415,2001
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
0.5 gm/kg
|
Behavioral - changes in motor activity (specific assay)
|
NNAPBA Naunyn-Schmiedebergs Archiv fuer Pharmakologie. (Berlin, Ger.) V.264-271, 1969-71. For publisher information, see NSAPCC. Volume(issue)/page/year: 367,414,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
3000 mg/kg
|
Behavioral - sleep
|
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998- Volume(issue)/page/year: 73,270,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
2 gm/kg
|
Brain and Coverings - other degenerative changes
Endocrine - differential effect of sex or castration on observed toxicity
Biochemical - Metabolism (Intermediary) - other
|
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 484,241,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
0.5 gm/kg
|
Brain and Coverings - other degenerative changes
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 133,255,2002
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
1 gm/kg
|
Sense Organs and Special Senses (Taste) - change in function
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 167,130,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
4.25 gm/kg
|
Behavioral - sleep
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 174,283,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
2.4 mg/kg
|
Brain and Coverings - other degenerative changes
Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 169,60,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
5250 mg/kg
|
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 26,451,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
2 mg/kg
|
Brain and Coverings - recordings from specific areas of CNS
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 145,69,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
0.5 gm/kg
|
Cardiac - pulse rate increase, without fall in BP
Vascular - BP elevation not characterized in autonomic section
Endocrine - other changes
|
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 25,537,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human
|
0.5 gm/kg
|
Behavioral - somnolence (general depressed activity)
Behavioral - changes in psychophysiological tests
|
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 28,371,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human
|
1.4 gm/kg
|
Behavioral - euphoria
Behavioral - changes in psychophysiological tests
Gastrointestinal - nausea or vomiting
|
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 28,740,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
0.8 gm/kg
|
Brain and Coverings - changes in surface EEG
Behavioral - changes in psychophysiological tests
|
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 28,747,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
1.5 gm/kg
|
Biochemical - Neurotransmitters or modulators (putative) - dopamine in striatum
|
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 28,939,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
1.14 mL/kg
|
Behavioral - changes in psychophysiological tests
|
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 28,1366,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
1.25 mg/kg
|
Behavioral - changes in motor activity (specific assay)
|
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 28,2124,2003
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - rat
|
0.5 gm/kg
|
Brain and Coverings - recordings from specific areas of CNS
|
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 29,530,2004
|
|
LDLo - Lowest published lethal dose
|
Intraperitoneal
|
Rodent - mouse
|
4000 mg/kg
|
Behavioral - alteration of classical conditioning
Nutritional and Gross Metabolic - body temperature decrease
|
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 499,285,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
0.6 gm/kg
|
Behavioral - changes in psychophysiological tests
Endocrine - other changes
|
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 29,1156,2004
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Human - man
|
0.57 gm/kg
|
Behavioral - changes in psychophysiological tests
|
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 29,1527,2004
|
|
LD50 - Lethal dose, 50 percent kill
|
Oral
|
Rodent - rat
|
7 gm/kg
|
Details of toxic effects not reported other than lethal dose value
|
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #6696575
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Primate - monkey
|
102 mg/kg
|
Behavioral - alteration of operant conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 170,1,2003
|
|
TDLo - Lowest published toxic dose
|
Intracerebral
|
Rodent - rat
|
363.6 ug/kg
|
Behavioral - alteration of operant conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 170,51,2003
|
|
TDLo - Lowest published toxic dose
|
Multiple routes
|
Human - man
|
3660 mg/kg
|
Endocrine - evidence of thyroid hypofunction
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 170,213,2003
|
|
TDLo - Lowest published toxic dose
|
Intracerebral
|
Rodent - rat
|
106 ug/kg
|
Behavioral - changes in motor activity (specific assay)
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 170,368,2003
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Human
|
0.89 mL/kg
|
Vascular - regional or general arteriolar constriction
Vascular - measurement of regional blood flow
|
JKMSEH Journal of Korean Medical Science. (Korean Academy of Medical Science, C.P.O. Box 2062, Seoul, S. Korea) V.1- 1986- Volume(issue)/page/year: 19,51,2004
|
|
TDLo - Lowest published toxic dose
|
Intraarterial
|
Human - man
|
0.071 mL/kg
|
Vascular - acute arterial occlusion
|
JKMSEH Journal of Korean Medical Science. (Korean Academy of Medical Science, C.P.O. Box 2062, Seoul, S. Korea) V.1- 1986- Volume(issue)/page/year: 18,585,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
3 gm/kg
|
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 197,206,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
500 mg/kg
|
Behavioral - analgesia
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 171,204,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human
|
400 mg/kg
|
Behavioral - alteration of operant conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 172,68,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
1000 mg/kg
|
Behavioral - aggression
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 172,255,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
5000 mg/kg
|
Endocrine - other changes
Blood - changes in other cell count (unspecified)
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,184,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
5000 mg/kg
|
Endocrine - other changes
Blood - changes in other cell count (unspecified)
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,184,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
6000 mg/kg
|
Blood - changes in spleen
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,184,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
5000 mg/kg
|
Immunological Including Allergic - decrease in cellular immune response
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,184,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Mammal - species unspecified
|
4000 mg/kg
|
Endocrine - other changes
Immunological Including Allergic - decrease in humoral immune response
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,184,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
5000 mg/kg
|
Liver - other changes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,213,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1500 mg/kg
|
Behavioral - alteration of classical conditioning
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,224,2005
|
|
TDLo - Lowest published toxic dose
|
Unreported
|
Rodent - rat
|
3 gm/kg
|
Brain and Coverings - other degenerative changes
Biochemical - Metabolism (Intermediary) - other proteins
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 150,325,2004
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Rodent - mouse
|
5 gm/kg
|
Liver - hepatitis (hepatocellular necrosis), zonal
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 66,119,2002
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
0.25 gm/kg
|
Behavioral - alteration of operant conditioning
|
JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987- Volume(issue)/page/year: 17,293,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
0.5 gm/kg
|
Behavioral - changes in motor activity (specific assay)
Behavioral - alteration of operant conditioning
|
JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987- Volume(issue)/page/year: 17,293,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human
|
0.5 mg/kg
|
Behavioral - changes in psychophysiological tests
|
JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987- Volume(issue)/page/year: 17,379,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
6000 mg/kg
|
Immunological Including Allergic - decrease in cellular immune response
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,28,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Mammal - dog
|
2 gm/kg
|
Behavioral - changes in psychophysiological tests
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 66,263,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
5 gm/kg
|
Behavioral - anticonvulsant
|
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 79,610,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
0.72 gm/kg
|
Behavioral - abuse
Endocrine - differential effect of sex or castration on observed toxicity
|
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 37,1511,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
1.5 mg/kg
|
Behavioral - antianxiety
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 177,84,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
2 gm/kg
|
Behavioral - alteration of operant conditioning
Behavioral - changes in psychophysiological tests
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 176,166,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
2.5 gm/kg
|
Behavioral - somnolence (general depressed activity)
Behavioral - alteration of operant conditioning
Behavioral - changes in psychophysiological tests
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 176,166,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
10.5 gm/kg/2H
|
Brain and Coverings - other degenerative changes
Biochemical - Metabolism (Intermediary) - other
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,380,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
4 gm/kg
|
Behavioral - somnolence (general depressed activity)
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 174,358,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
6 gm/kg
|
Behavioral - alteration of classical conditioning
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 175,189,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
2 mg/kg
|
Behavioral - changes in motor activity (specific assay)
Behavioral - alteration of classical conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 174,291,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
1 gm/kg
|
Behavioral - antianxiety
Behavioral - changes in psychophysiological tests
|
HOBEAO Hormones and Behavior. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 49,123,2006
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
1000 mg/kg
|
Liver - other changes
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 577S,1,2005
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
0.25 gm/kg
|
Behavioral - analgesia
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 309,86,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
5000 mg/kg
|
Behavioral - general anesthetic
|
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
6000 mg/kg
|
Behavioral - changes in psychophysiological tests
|
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
2 gm/kg
|
Behavioral - changes in psychophysiological tests
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 314,675,2005
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
1000 mg/kg
|
Behavioral - food intake (animal)
|
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 519,96,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human
|
0.7 gm/kg/10M
|
Behavioral - changes in psychophysiological tests
|
JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987- Volume(issue)/page/year: 19,627,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
1.5 mg/kg
|
Behavioral - alteration of classical conditioning
|
ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000- Volume(issue)/page/year: 24,1137,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
2000 mg/kg
|
Brain and Coverings - other degenerative changes
Biochemical - Metabolism (Intermediary) - other
|
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 520,51,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
625 mg/kg
|
Cardiac - pulse rate
Cardiac - change in rate
Nutritional and Gross Metabolic - body temperature increase
|
ECPPH* Experimental and Clinical Psychopharmacology (Washington Dc American Psychological Association) V.1- 1993- Volume(issue)/page/year: 2,53,1994
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
4 gm/kg
|
Behavioral - withdrawal
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 319,219,2006
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
2.0 gm/kg
|
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature decrease
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 319,219,2006
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
2 gm/kg
|
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphokinase
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 319,1366,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
4 mL/kg
|
Gastrointestinal - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
|
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993- Volume(issue)/page/year: 29,1973,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
10 mL/kg
|
Gastrointestinal - ulceration or bleeding from stomach
Gastrointestinal - other changes
|
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993- Volume(issue)/page/year: 29,2206,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
10 mL/kg
|
Gastrointestinal - other changes
|
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993- Volume(issue)/page/year: 29,2206,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
4300 mg/kg
|
Vascular - measurement of regional blood flow
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 235,141,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
6000 mg/kg
|
Biochemical - Metabolism (Intermediary) - other
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 235,141,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
500 mg/kg
|
Liver - other changes
Biochemical - Metabolism (Intermediary) - other
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 223,225,2007
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
4930 mg/m3
|
Details of toxic effects not reported other than lethal dose value
|
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,76,1979
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
1110 mg/m3/4H
|
Details of toxic effects not reported other than lethal dose value
|
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,76,1979
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human
|
600 mg/kg
|
Cardiac - change in rate
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - other changes
|
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 42,761,2004
|
|
LD50 - Lethal dose, 50 percent kill
|
Intravenous
|
Rodent - mouse
|
1973 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 Volume(issue)/page/year: ,706,2005
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
1000 mg/kg
|
Behavioral - muscle weakness
|
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 27,1064,2006
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
2000 mg/kg
|
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Behavioral - alteration of operant conditioning
|
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 27,1064,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
650 mg/kg
|
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Behavioral - alteration of operant conditioning
|
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 27,1064,2006
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
500 mg/kg
|
Behavioral - alteration of classical conditioning
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 29,23,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
3000 mg/kg
|
Brain and Coverings - other degenerative changes
Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion)
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 169,253,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human
|
0.1 gm/kg
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
|
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972- Volume(issue)/page/year: 369(Suppl 1),R106,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
1.5 gm/kg
|
Behavioral - changes in motor activity (specific assay)
Behavioral - antianxiety
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 191,311,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
2 gm/kg
|
Behavioral - ataxia
Behavioral - alteration of classical conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 191,311,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
3.5 gm/kg
|
Behavioral - altered sleep time (including change in righting reflex)
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 191,311,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
0.4 gm/kg
|
Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 191,679,2007
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Human - man
|
0.571 gm/kg
|
Brain and Coverings - other degenerative changes
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 191,975,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
0.3 mg/kg
|
Behavioral - alteration of operant conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 192,39,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
1.2 mg/kg
|
Behavioral - changes in motor activity (specific assay)
Behavioral - antianxiety
Behavioral - alteration of operant conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 192,39,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
1.8 mg/kg
|
Behavioral - alteration of classical conditioning
Behavioral - antianxiety
Behavioral - alteration of operant conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 192,39,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
0.45 gm/kg
|
Behavioral - changes in psychophysiological tests
|
ALCOH* Alcohol (Fayetteville, N.Y., New York Ny : Elsevier Science) V.1- 1984- Volume(issue)/page/year: 4,293,1987
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - rabbit
|
0.8 gm/kg
|
Brain and Coverings - changes in surface EEG
|
PHREP* Pharmacological reports : PR (Krakow, Poland : Institute of Pharmacology, Polish Academy of Sciences) V.57- 2005- Volume(issue)/page/year: 57,61,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
4.44 mL/kg
|
Gastrointestinal - ulceration or bleeding from stomach
Gastrointestinal - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
|
PHREP* Pharmacological reports : PR (Krakow, Poland : Institute of Pharmacology, Polish Academy of Sciences) V.57- 2005- Volume(issue)/page/year: 57,481,2005
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
2 gm/kg
|
Brain and Coverings - recordings from specific areas of CNS
Behavioral - anticonvulsant
|
JPHPH* Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. (Krakow Polish Physiological Society) V.42- 2001- Volume(issue)/page/year: 58,641,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
3 gm/kg
|
Behavioral - sleep
|
JPHSC* Journal of pharmacological sciences (Kyoto, Japan : Japanese Pharmacological Society) V.91- 2003- Volume(issue)/page/year: 106,361,2008
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - rabbit
|
0.8 gm/kg
|
Brain and Coverings - changes in surface EEG
Behavioral - ataxia
|
PHREP* Pharmacological reports : PR (Krakow, Poland : Institute of Pharmacology, Polish Academy of Sciences) V.57- 2005- Volume(issue)/page/year: 58,890,2006
|
|
LDLo - Lowest published lethal dose
|
Unreported
|
Rodent - mouse
|
2 gm/kg
|
Details of toxic effects not reported other than lethal dose value
|
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 32,421,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
4 gm/kg
|
Immunological Including Allergic - decreased immune response
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,276,2008
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
2 gm/kg
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 46,1739,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
12800 mg/kg
|
Gastrointestinal - ulceration or bleeding from stomach
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 47,134,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
4.8 gm/kg
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
Biochemical - Metabolism (Intermediary) - effect on mitochondrial function
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 252,86,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
2 gm/kg
|
Behavioral - altered sleep time (including change in righting reflex)
|
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 41,782,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
6.45 mL/kg
|
Gastrointestinal - ulceration or bleeding from stomach
Gastrointestinal - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
|
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993- Volume(issue)/page/year: 31,1351,2008
|
|
LD50 - Lethal dose, 50 percent kill
|
Oral
|
Rodent - rat
|
15010 mg/kg
|
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - gastritis
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
LDLo - Lowest published lethal dose
|
Oral
|
Rodent - rat
|
7000 mg/kg
|
Lungs, Thorax, or Respiration - respiratory depression
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
LD50 - Lethal dose, 50 percent kill
|
Oral
|
Rodent - rabbit
|
6300 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
LDLo - Lowest published lethal dose
|
Oral
|
Mammal - cat
|
6000 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
LDLo - Lowest published lethal dose
|
Oral
|
Mammal - dog
|
5500 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
LD50 - Lethal dose, 50 percent kill
|
Oral
|
Rodent - guinea pig
|
5560 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
LC50 - Lethal concentration, 50 percent kill
|
Inhalation
|
Rodent - mouse
|
>60000 ppm/1H
|
Behavioral - ataxia
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - mouse
|
13300 ppm/1.33H
|
Behavioral - ataxia
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - mouse
|
23940 ppm/1.25H
|
Behavioral - general anesthetic
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
LCLo - Lowest published lethal concentration
|
Inhalation
|
Rodent - mouse
|
29300 ppm/7H
|
Behavioral - general anesthetic
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - mouse
|
31900 ppm/0.33H
|
Behavioral - ataxia
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
LC50 - Lethal concentration, 50 percent kill
|
Inhalation
|
Rodent - rat
|
5900 mg/m3/6H
|
Details of toxic effects not reported other than lethal dose value
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
LC50 - Lethal concentration, 50 percent kill
|
Inhalation
|
Rodent - rat
|
124700 mg/m3/4H
|
Details of toxic effects not reported other than lethal dose value
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - guinea pig
|
12850 ppm/8.75H
|
Behavioral - general anesthetic
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
LCLo - Lowest published lethal concentration
|
Inhalation
|
Rodent - guinea pig
|
21900 ppm/9.8H
|
Behavioral - general anesthetic
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
LC50 - Lethal concentration, 50 percent kill
|
Inhalation
|
Rodent - mouse
|
39000 mg/m3/4H
|
Details of toxic effects not reported other than lethal dose value
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Human
|
1800 ppm/30M
|
Lungs, Thorax, or Respiration - bronchiolar constriction
Lungs, Thorax, or Respiration - cough
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
LDLo - Lowest published lethal dose
|
Administration onto the skin
|
Rodent - rabbit
|
20000 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Rodent - rat
|
7900 mg/kg
|
Reproductive - Maternal Effects - menstrual cycle changes or disorders
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
2500 mg/kg
|
Endocrine - changes in luteinizing hormone
Endocrine - androgenic
Reproductive - Paternal Effects - testes, epididymis, sperm duct
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1000 mg/kg
|
Behavioral - alteration of operant conditioning
|
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- Volume(issue)/page/year: 89,179,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
3.08 mL/kg
|
Gastrointestinal - ulceration or bleeding from stomach
|
PYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994- Volume(issue)/page/year: 9,125,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
4.57 mL/kg
|
Gastrointestinal - ulceration or bleeding from stomach
Biochemical - Metabolism (Intermediary) - other
|
PYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994- Volume(issue)/page/year: 9,515,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
6000 mg/kg
|
Liver - other changes
Biochemical - Metabolism (Intermediary) - effect on mitochondrial function
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,237,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
4.8 mL/kg
|
Gastrointestinal - ulceration or bleeding from stomach
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
Biochemical - Metabolism (Intermediary) - effect on active transport
|
PYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994- Volume(issue)/page/year: 12,264,2005
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
1.5 gm/kg
|
Behavioral - alteration of classical conditioning
|
PYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994- Volume(issue)/page/year: 15,587,2008
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
4.4 gm/kg
|
Brain and Coverings - other degenerative changes
|
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 30,459,2009
|
|
LD50 - Lethal dose, 50 percent kill
|
Oral
|
Rodent - mouse
|
10.5 mL/kg
|
Details of toxic effects not reported other than lethal dose value
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
LD50 - Lethal dose, 50 percent kill
|
Intravenous
|
Rodent - mouse
|
2.8 mL/kg
|
Details of toxic effects not reported other than lethal dose value
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
LD50 - Lethal dose, 50 percent kill
|
Intraperitoneal
|
Rodent - mouse
|
4 mL/kg
|
Details of toxic effects not reported other than lethal dose value
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
LC50 - Lethal concentration, 50 percent kill
|
Inhalation
|
Rodent - mouse
|
>40000 ppm/10M
|
Behavioral - ataxia
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
1500 mg/kg
|
Behavioral - changes in motor activity (specific assay)
Nutritional and Gross Metabolic - body temperature decrease
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 197,67,2008
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
2800 mg/kg
|
Brain and Coverings - other degenerative changes
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 201,261,2008
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
1.5 mg/kg
|
Behavioral - alteration of classical conditioning
Behavioral - alteration of operant conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 200,105,2008
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
1000 mg/kg
|
Nutritional and Gross Metabolic - body temperature decrease
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 197,409,2008
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
3 gm/kg
|
Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 322,1003,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1 gm/kg
|
Cardiac - change in rate
Cardiac - cardiac output
Vascular - BP lowering not characterized in autonomic section
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 324,368,2008
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
2700 mg/kg
|
Behavioral - ataxia
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 194,139,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
3.9 gm/kg
|
Gastrointestinal - gastritis
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 579,214,2005
|
|
TCLo - Lowest published toxic concentration
|
Multiple routes
|
Non-mammalian species
|
1 pph/30M
|
Behavioral - changes in motor activity (specific assay)
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 32,84,2010
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Mammal - cat
|
2 gm/kg
|
Brain and Coverings - recordings from specific areas of CNS
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 243,348,2010
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - rat
|
0.72 gm/kg/10M
|
Spinal Cord - other degenerative changes
Vascular - BP lowering not characterized in autonomic section
|
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 158,806,2009
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - rat
|
1.03 gm/kg/40M
|
Spinal Cord - other degenerative changes
Behavioral - tolerance
|
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 158,806,2009
|
|
LCLo - Lowest published lethal concentration
|
Chemical added to tank with water (dissolved in water)
|
Fish - zebrafish
|
1 gm/L/144H
|
Details of toxic effects not reported other than lethal dose value
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 102,162,2011
|
|
TCLo - Lowest published toxic concentration
|
Chemical added to tank with water (dissolved in water)
|
Fish - zebrafish
|
0.01 gm/L/144H
|
Behavioral - changes in motor activity (specific assay)
Behavioral - alteration of classical conditioning
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 102,162,2011
|
|
ICLo - Inhibitor Concentration Low
|
In vitro
|
Mouse - fibroblast
|
>428.2 mmol/L/24H
|
In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 1,3,1987
|
|
ICLo - Inhibitor Concentration Low
|
In vitro
|
Mouse - macrophage
|
>513 mmol/L/24H
|
In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 1,3,1987
|
|
ICLo - Inhibitor Concentration Low
|
In vitro
|
Hamster - lung fibroblast
|
>478.8 mmol/L/24H
|
In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 1,3,1987
|
|
ICLo - Inhibitor Concentration Low
|
In vitro
|
Human - liver tumor
|
>428.2 mmol/L/24H
|
In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 1,3,1987
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Human - liver tumor
|
716 mmol/L/24H
|
In Vitro Toxicity Studies - cell protein synthesis
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 3,189,1989
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Rabbit - ocular
|
0.06 gm/L/10M
|
In Vitro Toxicity Studies - cell viability (cell death), unspecified assay
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 3,329,1989
|
|
ICLo - Inhibitor Concentration Low
|
In vitro
|
Human - lung fibroblast
|
0.1 gm/L/7D
|
In Vitro Toxicity Studies - cell proliferation: DNA incorporation, mitotic index etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 4,1,1990
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Mouse - liver
|
1372 mmol/L/2H
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 4,783,1990
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Rat - liver
|
>39450 mg/L/20H
|
In Vitro Toxicity Studies - cell membrane integrity: cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Rat - liver
|
>39450 mg/L/20H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Rat - liver
|
>39450 mg/L/20H
|
In Vitro Toxicity Studies - cell protein synthesis
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Rat - liver
|
>39450 mg/L/20H
|
In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Rat - liver tumor
|
>39450 mg/L/20H
|
In Vitro Toxicity Studies - cell membrane integrity: cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Rat - liver tumor
|
>39450 mg/L/20H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Rat - liver tumor
|
>33450 mg/L/20H
|
In Vitro Toxicity Studies - cell protein synthesis
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Rat - liver tumor
|
>39450 mg/L/20H
|
In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Human - liver
|
303 umol/L/24H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992
|
|
IC10 - Inhibitor Concentration 10
|
In vitro
|
Human - liver
|
126 umol/L/24H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Rat - liver
|
620 umol/L/24H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992
|
|
IC10 - Inhibitor Concentration 10
|
In vitro
|
Rat - liver
|
174 umol/L/24H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Mouse - fibroblast
|
854 umol/L/24H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992
|
|
IC10 - Inhibitor Concentration 10
|
In vitro
|
Mouse - fibroblast
|
521 umol/L/24H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Human - skin
|
29000 mg/L/48H
|
In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,367,1992
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Human - skin
|
139000 mg/L/1M
|
In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,367,1992
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Rat - lung
|
3.8 gm/L/24H
|
In Vitro Toxicity Studies - cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,111,1993
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Rat - lung
|
12.9 gm/L/24H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,111,1993
|
|
IC10 - Inhibitor Concentration 10
|
In vitro
|
Rat - lung
|
0.26 gm/L/24H
|
In Vitro Toxicity Studies - cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,111,1993
|
|
IC75 - Inhibitor Concentration 75
|
In vitro
|
Rat - lung
|
20 gm/L/24H
|
In Vitro Toxicity Studies - cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,111,1993
|
|
IC10 - Inhibitor Concentration 10
|
In vitro
|
Rat - lung
|
0.62 gm/L/24H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,111,1993
|
|
IC75 - Inhibitor Concentration 75
|
In vitro
|
Rat - lung
|
85.1 gm/L/24H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,111,1993
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Hamster - lung fibroblast
|
147.5 mmol/L/60H
|
In Vitro Toxicity Studies - cell counting
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,511,1993
|
|
IC10 - Inhibitor Concentration 10
|
In vitro
|
Hamster - lung fibroblast
|
16 mmol/L/60H
|
In Vitro Toxicity Studies - cell counting
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,511,1993
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Human - HeLa cell
|
157.5 mmol/L/60H
|
In Vitro Toxicity Studies - cell counting
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,511,1993
|
|
IC10 - Inhibitor Concentration 10
|
In vitro
|
Human - HeLa cell
|
48 mmol/L/60H
|
In Vitro Toxicity Studies - cell counting
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,511,1993
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Non-mammalian species - fibroblast
|
254 mmol/L/24H
|
In Vitro Toxicity Studies - cell counting
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,537,1993
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Chicken - neurons
|
200422 umol/L/21H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,653,1993
|
|
IC10 - Inhibitor Concentration 10
|
In vitro
|
Chicken - neurons
|
16072 umol/L/21H
|
In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,653,1993
|
|
IC50 - Inhibitor Concentration 50
|
In vitro
|
Chicken - neurons
|
134186 umol/L/20H
|
In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,653,1993
|
|
IC10 - Inhibitor Concentration 10
|
In vitro
|
Chicken - neurons
|
28898 umol/L/20H
|
In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc.
|
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,653,1993
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
2.375 mL/kg
|
Gastrointestinal - ulceration or bleeding from stomach
|
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 134,904,2011
|
|
LC - Lethal concentration
|
Inhalation
|
Rodent - rat
|
>29430 mg/m3/7H
|
Details of toxic effects not reported other than lethal dose value
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
| OTHER MULTIPLE DOSE TOXICITY DATA |
| Type of Test |
Route of Exposure or Administration |
Species/Test System |
Dose Data |
Toxic Effects |
Reference |
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1825 gm/kg/1Y (continuous)
|
Liver - fatty liver degeneration
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
DDSCDJ Digestive Diseases and Sciences. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.24- 1979- Volume(issue)/page/year: 25,587,1980
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
19 gm/kg/21D (continuous)
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 12,265,1982
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
280 gm/kg/5W (intermittent)
|
Cardiac - changes in heart weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Related to Chronic Data - changes in testicular weight
|
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 8,243,1983
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
851 gm/kg/10W (continuous)
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
|
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 38,260,1976
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
7 mL/kg/7D (intermittent)
|
Liver - other changes
Biochemical - Effect on specific coenzyme - B vitamins including folate
|
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 10(1-2),25,1978
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
6300 mg/kg/9W (intermittent)
|
Liver - other changes
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
|
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 64(1),46,1999
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Mammal - dog
|
560 mL/kg/10W (continuous)
|
Brain and Coverings - other degenerative changes
Cardiac - other changes
Liver - other changes
|
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 128,1021,1968
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Primate - monkey
|
210 gm/kg/5W (intermittent)
|
Liver - fatty liver degeneration
|
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 8,243,1983
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
45 gm/kg/30D (intermittent)
|
Behavioral - changes in psychophysiological tests
|
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: -,64,1993
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
3500 gm/kg/10W (continuous)
|
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 225,479,1983
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
2100 gm/kg/5W (continuous)
|
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 225,479,1983
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
1750 gm/kg/5W (continuous)
|
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 225,479,1983
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - mouse
|
8000 mg/m3/4H/17W (intermittent)
|
Brain and Coverings - other degenerative changes
Endocrine - other changes
Immunological Including Allergic - decreased immune response
|
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1994
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
8000 mg/m3/4H/17W (intermittent)
|
Brain and Coverings - other degenerative changes
Endocrine - other changes
Immunological Including Allergic - decreased immune response
|
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1994
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rabbit
|
8000 mg/m3/4H/17W (intermittent)
|
Brain and Coverings - other degenerative changes
Endocrine - other changes
Immunological Including Allergic - decreased immune response
|
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1994
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
62.5 gm/kg/5D (continuous)
|
Brain and Coverings - other degenerative changes
Endocrine - effect on menstrual cycle
Endocrine - changess in gonadotropins
|
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 37,1089,1987
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
62.5 gm/kg/6D (continuous)
|
Endocrine - effect on menstrual cycle
|
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 37,1089,1987
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
448 gm/kg/4W (continuous)
|
Behavioral - fluid intake
|
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: #PB85118651
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
65 gm/kg/13D (continuous)
|
Endocrine - other changes
|
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 138,389,1997
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
900 mL/kg/62D (continuous)
|
Behavioral - fluid intake
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 24,275,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
240000 mg/kg/30D (intermittent)
|
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 47,82,1984
|
|
TDLo - Lowest published toxic dose
|
Intramuscular
|
Rodent - rat
|
420 gm/kg/6W (intermittent)
|
Liver - hepatitis (hepatocellular necrosis), diffuse
Liver - fatty liver degeneration
Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 299,832,2001
|
|
TDLo - Lowest published toxic dose
|
Intramuscular
|
Rodent - mouse
|
42 gm/kg/14D (intermittent)
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
Liver - other changes
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 46,103,1983
|
|
TDLo - Lowest published toxic dose
|
Intramuscular
|
Rodent - mouse
|
63 gm/kg/21D (intermittent)
|
Liver - fatty liver degeneration
Liver - liver function tests impaired
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 46,103,1983
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
35000 mg/kg/7D (intermittent)
|
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 59,44,1996
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
115000 mg/kg/23D (intermittent)
|
Behavioral - alteration of classical conditioning
|
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 59,44,1996
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
67.5 mg/kg/15D (continuous)
|
Brain and Coverings - other degenerative changes
Biochemical - Metabolism (Intermediary) - xanthine, purine or nucleotides including urate
Biochemical - Metabolism (Intermediary) - other proteins
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 296,857,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
93.8 mL/kg/2W (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
Biochemical - Metabolism (Intermediary) - lipids including transport
|
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 22,207,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
882 gm/kg/75D (intermittent)
|
Musculoskeletal - other changes
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 301,1132,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
72 gm/kg/7D (continuous)
|
Kidney/Ureter/Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,315,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
908 mg/kg/4W (continuous)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
|
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 22,207,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1372 gm/kg/20W (continuous)
|
Behavioral - food intake (animal)
Vascular - regional or general arteriolar constriction
Vascular - other changes
|
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974- Volume(issue)/page/year: 29,707,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
24000 mL/kg/120D (continuous)
|
Kidney/Ureter/Bladder - other changes in urine composition
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,195,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
36000 mL/kg/180D (continuous)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,195,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
36000 mL/kg/180D (continuous)
|
Liver - other changes
Nutritional and Gross Metabolic - changes in iron
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,195,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
8 mg/kg/4D (intermittent)
|
Brain and Coverings - other degenerative changes
Biochemical - Metabolism (Intermediary) - other proteins
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,127,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
9660 gm/kg/56W (intermittent)
|
Cardiac - change in resting or action potential
Endocrine - differential effect of sex or castration on observed toxicity
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 189,196,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
240 gm/kg/60D (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
|
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 42,367,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
12 gm/kg/20D (continuous)
|
Behavioral - tolerance
Behavioral - alteration of operant conditioning
|
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 477,129,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Primate - monkey
|
260 gm/kg/2Y (intermittent)
|
Behavioral - alteration of classical conditioning
Behavioral - aggression
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 165,1,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
210 gm/kg/10W (continuous)
|
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - lipids including transport
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 41,1551,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
4500 gm/kg/24W (intermittent)
|
Behavioral - food intake (animal)
Cardiac - change in force of contraction
Endocrine - differential effect of sex or castration on observed toxicity
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 179,111,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
84 gm/kg/4W (intermittent)
|
Behavioral - food intake (animal)
Endocrine - other changes
Nutritional and Gross Metabolic - other changes
|
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 36,125,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
14 gm/kg/7D (intermittent)
|
Brain and Coverings - other degenerative changes
|
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 36,503,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
28 gm/kg/7D (intermittent)
|
Brain and Coverings - other degenerative changes
Biochemical - Neurotransmitters or modulators (putative) - catecholamine levels in CNS
Biochemical - Neurotransmitters or modulators (putative) - dopamine in striatum
|
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 36,503,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
4.8 mg/kg/4D (intermittent)
|
Behavioral - changes in motor activity (specific assay)
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 160,48,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
875 mg/kg/10W (intermittent)
|
Kidney/Ureter/Bladder - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
Biochemical - Metabolism (Intermediary) - effect on Sodium-Potassium pump
|
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 71,2881,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
1120 gm/kg/4W (intermittent)
|
Blood - changes in spleen
Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
|
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998- Volume(issue)/page/year: 73,72,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
41.6 gm/kg/4D (continuous)
|
Behavioral - analgesia
|
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 73,3351,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
130 gm/kg/10D (continuous)
|
Behavioral - tolerance
Behavioral - withdrawal
|
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 73,3351,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
36000 mg/kg/6D (continuous)
|
Behavioral - changes in motor activity (specific assay)
Behavioral - alteration of classical conditioning
Behavioral - alteration of operant conditioning
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 26,35,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
8 gm/kg/10D (intermittent)
|
Behavioral - abuse
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 168,208,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
300 gm/kg/12W (intermittent)
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 42,429,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
27000 mg/kg/6D (intermittent)
|
Brain and Coverings - other degenerative changes
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 26,353,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
31500 mg/kg/6D (intermittent)
|
Cardiac - change in rate
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 26,451,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
12 mg/kg/3D (intermittent)
|
Behavioral - alteration of classical conditioning
|
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 138,9,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
21000 mg/kg/7D (intermittent)
|
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)
|
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 138,1376,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
15 gm/kg/15D (intermittent)
|
Endocrine - androgenic
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 17,641,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
30 gm/kg/15D (intermittent)
|
Endocrine - estrogenic
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 17,641,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
90 gm/kg/15D (intermittent)
|
Reproductive - Paternal Effects - testes, epididymis, sperm duct
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 17,641,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - man
|
4623 gm/kg/12Y (intermittent)
|
Brain and Coverings - other degenerative changes
|
DADEDV Drug and Alcohol Dependence. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 65,159,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
108 gm/kg/4W (intermittent)
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases
Liver - other changes
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 42,2045,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
10400 mg/kg/13D (intermittent)
|
Endocrine - estrogenic
|
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 90,2225,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
98800 mg/kg/13D (continuous)
|
Behavioral - withdrawal
Behavioral - alteration of classical conditioning
|
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 499,285,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
875 gm/kg/35D (continuous)
|
Liver - liver function tests impaired
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 197,206,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
42 gm/kg/7D (intermittent)
|
Behavioral - changes in psychophysiological tests
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 27,55,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
25000 mg/kg/5D (intermittent)
|
Behavioral - alteration of operant conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 171,204,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
420 gm/kg/10W (intermittent)
|
Brain and Coverings - other degenerative changes
Musculoskeletal - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 199,161,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Mammal - species unspecified
|
112000 mg/kg/28D (intermittent)
|
Immunological Including Allergic - decrease in cellular immune response
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,184,2005
|
|
TDLo - Lowest published toxic dose
|
Parenteral
|
Rodent - rat
|
50000 mg/kg/50D (intermittent)
|
Liver - hepatitis (hepatocellular necrosis), zonal
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,15,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
48000 mg/kg/12W (intermittent)
|
Cardiac - other changes
Vascular - BP elevation not characterized in autonomic section
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,46,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - hamster
|
512 mg/kg/30D (continuous)
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
|
CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8. Volume(issue)/page/year: 129,285,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - hamster
|
559 mg/kg/30D (continuous)
|
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
|
CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8. Volume(issue)/page/year: 129,285,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
6650 mL/kg/10W (continuous)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)
|
CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8. Volume(issue)/page/year: 131,161,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
480000 mg/kg/60D (continuous)
|
Gastrointestinal - changes in structure or function of endocrine pancreas
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,318,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
396 gm/kg/198D (continuous)
|
Liver - other changes
Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,14,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
396 gm/kg/198D (continuous)
|
Liver - other changes
Nutritional and Gross Metabolic - changes in iron
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,14,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
273000 mg/kg/21D (continuous)
|
Musculoskeletal - osteoporosis
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,354,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1428000 mg/kg/14D (continuous)
|
Behavioral - fluid intake
Liver - other changes
Nutritional and Gross Metabolic - conditioned vitamin deficiency
|
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 26,191,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
295.2 gm/kg/10W (intermittent)
|
Cardiac - cardiomyopathy including infarction
Cardiac - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphokinase
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,167,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
168 gm/kg/12W (intermittent)
|
Cardiac - other changes
Vascular - BP elevation not characterized in autonomic section
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,168,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
270 gm/kg/90D (intermittent)
|
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
Biochemical - Metabolism (Intermediary) - other proteins
|
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 78,276,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
54 gm/kg/9D (intermittent)
|
Endocrine - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Musculoskeletal - other changes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,280,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
54 gm/kg/9D (intermittent)
|
Endocrine - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Musculoskeletal - osteoporosis
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,280,2004
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
6130 ppm/4W (intermittent)
|
Endocrine - changes in thymus weight
|
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 25,193,2005
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
6130 ppm/4W (intermittent)
|
Brain and Coverings - other degenerative changes
Cardiac - changes in heart weight
Endocrine - hyperglycemia
|
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 25,193,2005
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
6130 ppm/4W (intermittent)
|
Biochemical - Metabolism (Intermediary) - other
|
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 25,193,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
15000 mg/kg/2D (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
Biochemical - Metabolism (Intermediary) - other
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,41,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
60 gm/kg/30D (intermittent)
|
Biochemical - Neurotransmitters or modulators (putative) - catecholamine levels in CNS
Biochemical - Neurotransmitters or modulators (putative) - dopamine in striatum
|
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 37,1839,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
4 gm/kg/8D (intermittent)
|
Behavioral - alteration of classical conditioning
Behavioral - changes in psychophysiological tests
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 176,50,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
50 gm/kg/10D (intermittent)
|
Liver - other changes
Biochemical - Metabolism (Intermediary) - other
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 182,58,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
600000 mg/kg/75D (intermittent)
|
Musculoskeletal - other changes
Nutritional and Gross Metabolic - changes in calcium
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,388,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
354000 mg/kg/30D (intermittent)
|
Musculoskeletal - other changes
Nutritional and Gross Metabolic - changes in calcium
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,388,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
462000 mg/kg/6W (intermittent)
|
Musculoskeletal - other changes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,388,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
31.5 gm/kg/6D (intermittent)
|
Behavioral - changes in psychophysiological tests
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 27,815,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
35 gm/kg/5W (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
Biochemical - Metabolism (Intermediary) - other proteins
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 215,234,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
126 gm/kg/12W (continuous)
|
Vascular - BP lowering not characterized in autonomic section
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 306,271,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
400 gm/kg/8W (intermittent)
|
Brain and Coverings - recordings from specific areas of CNS
Behavioral - withdrawal
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 307,566,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
204 gm/kg/68D (continuous)
|
Reproductive - Maternal Effects - other effects
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 308,644,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
52800 mg/kg/6D (intermittent)
|
Behavioral - convulsions or effect on seizure threshold
Behavioral - withdrawal
Gastrointestinal - other changes
|
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
52800 mg/kg/6D (intermittent)
|
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
|
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
52800 mg/kg/6D (intermittent)
|
Related to Chronic Data - death
|
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
30 gm/kg/3D (continuous)
|
Biochemical - Effect on specific coenzyme - proportion of isoenzymes
Liver - other changes
|
ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000- Volume(issue)/page/year: 24,831,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
195 gm/kg/30D (continuous)
|
Brain and Coverings - other degenerative changes
|
ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000- Volume(issue)/page/year: 24,930,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
95200 mg/kg/4W (intermittent)
|
Behavioral - food intake (animal)
Behavioral - fluid intake
|
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: TR-510
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
78400 mg/kg/4W (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)
|
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: TR-510
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
496000 mg/kg/80W (intermittent)
|
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: TR-510
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
2920000 mg/kg/2Y (intermittent)
|
Liver - other changes
Liver - tumors
Liver - changes in liver weight
|
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: TR-510
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
5256000 mg/kg/2Y (intermittent)
|
Liver - tumors
|
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: TR-510
|
|
-
|
Subcutaneous
|
Rodent - mouse
|
5000 mg/kg/20D (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 44,588,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
420000 mg/kg/12W (intermittent)
|
Liver - other changes
Kidney/Ureter/Bladder - other changes in urine composition
Kidney/Ureter/Bladder - other changes
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 219,11,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
210 gm/kg/6W (intermittent)
|
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
|
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993- Volume(issue)/page/year: 27,1636,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
470220 mg/kg/51D (continuous)
|
Musculoskeletal - osteoporosis
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 220,302,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human
|
149 units/kg/4Y (intermittent)
|
Skin and Appendages - dermatitis, other (after systemic exposure)
|
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951- Volume(issue)/page/year: 155,195,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
284.4 gm/kg/45D (intermittent)
|
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Metabolism (Intermediary) - lipids including transport
|
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 22,149,2003
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
4930 mg/m3/4D (intermittent)
|
Peripheral Nerve and Sensation - recording from peripheral motor nerve
Lungs, Thorax, or Respiration - other changes
|
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,76,1979
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
4930 mg/m3/8D (intermittent)
|
Behavioral - alteration of classical conditioning
|
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,76,1979
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
4930 mg/m3/14D (intermittent)
|
Behavioral - changes in motor activity (specific assay)
|
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,76,1979
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
1110 mg/m3/14D (intermittent)
|
Vascular - other changes
|
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,76,1979
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
50.4 gm/kg/7D (continuous)
|
Brain and Coverings - other degenerative changes
Behavioral - abuse
|
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 143,455,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
300000 mg/kg/12W (intermittent)
|
Liver - other changes
Kidney/Ureter/Bladder - other changes
Nutritional and Gross Metabolic - conditioned vitamin deficiency
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 45,1478,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
216000 mg/kg/90D (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 45,1333,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
84 gm/kg/5W (continuous)
|
Cardiac - cardiomyopathy including infarction
Cardiac - other changes
Cardiac - changes in heart weight
|
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972- Volume(issue)/page/year: 375(Suppl 1),60,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
84 gm/kg/5W (continuous)
|
Vascular - relaxation (isolated tissues)
|
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972- Volume(issue)/page/year: 375(Suppl 1),60,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
7000 mg/kg/7D (intermittent)
|
Behavioral - changes in psychophysiological tests
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 29,23,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
7000 mg/kg/7D (intermittent)
|
Behavioral - changes in psychophysiological tests
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 29,23,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
7000 mg/kg/7D (intermittent)
|
Behavioral - tolerance
Behavioral - changes in psychophysiological tests
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 29,23,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
315 gm/kg/9W (intermittent)
|
Vascular - BP elevation not characterized in autonomic section
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
|
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974- Volume(issue)/page/year: 33,183,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
151.2 gm/kg/21D (intermittent)
|
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
Behavioral - abuse
|
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 18,693,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
284.4 gm/kg/45D (intermittent)
|
Liver - hepatitis (hepatocellular necrosis), diffuse
Endocrine - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
|
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 20,129,2006
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
3 gm/kg/3D (intermittent)
|
Behavioral - alteration of classical conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 191,909,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
37.8 mg/kg/21D (intermittent)
|
Behavioral - changes in motor activity (specific assay)
Behavioral - tolerance
Behavioral - alteration of classical conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 192,39,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
12.6 mg/kg/21D (intermittent)
|
Behavioral - tolerance
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 192,39,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Primate - monkey
|
32.5 gm/kg/90D (intermittent)
|
Cardiac - change in rate
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 192,183,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
980 gm/kg/14W (intermittent)
|
Behavioral - food intake (animal)
Cardiac - cardiac output
Kidney/Ureter/Bladder - changes in blood vessels or in circulation of kidney
|
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998- Volume(issue)/page/year: 68,797,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1050 gm/kg/70D (intermittent)
|
Liver - other changes
Biochemical - Metabolism (Intermediary) - other proteins
|
ALCOH* Alcohol (Fayetteville, N.Y., New York Ny : Elsevier Science) V.1- 1984- Volume(issue)/page/year: 41,591,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
188 gm/kg/25D (intermittent)
|
Liver - fatty liver degeneration
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
Biochemical - Metabolism (Intermediary) - lipids including transport
|
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)- Volume(issue)/page/year: 39,43,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
14 gm/kg/19D (intermittent)
|
Behavioral - tolerance
Nutritional and Gross Metabolic - body temperature decrease
|
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 40,1517,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
16 gm/kg/19D (intermittent)
|
Nutritional and Gross Metabolic - body temperature decrease
|
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 40,1517,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
140 mL/kg/2W (continuous)
|
Brain and Coverings - other degenerative changes
Liver - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
|
PHREP* Pharmacological reports : PR (Krakow, Poland : Institute of Pharmacology, Polish Academy of Sciences) V.57- 2005- Volume(issue)/page/year: 58,876,2006
|
|
TDLo - Lowest published toxic dose
|
Unreported
|
Rodent - mouse
|
8 gm/kg/4D (intermittent)
|
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
|
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 32,421,2007
|
|
TDLo - Lowest published toxic dose
|
Unreported
|
Rodent - mouse
|
16 gm/kg/8D (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
Related to Chronic Data - death
|
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 32,421,2007
|
|
TDLo - Lowest published toxic dose
|
Unreported
|
Rodent - mouse
|
16 gm/kg/8D (intermittent)
|
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
Related to Chronic Data - death
|
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 32,421,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
980 gm/kg/8W (continuous)
|
Liver - changes in liver weight
Kidney/Ureter/Bladder - changes in kidney weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 46,1378,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
72 mL/kg/4W (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 46,1503,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
355.5 gm/kg/45D (intermittent)
|
Liver - other changes
Kidney/Ureter/Bladder - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 46,1627,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1814.4 gm/kg/12W (continuous)
|
Vascular - measurement of regional blood flow
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
Biochemical - Metabolism (Intermediary) - lipids including transport
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 46,1940,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
284.4 gm/kg/45D (intermittent)
|
Brain and Coverings - other degenerative changes
Biochemical - Metabolism (Intermediary) - lipids including transport
Biochemical - Metabolism (Intermediary) - effect on Sodium-Potassium pump
|
SIMEJ* Singapore medical journal(Singapore, Singapore Medical Assn.) V.1- 1960- Volume(issue)/page/year: 47,864,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
355.5 gm/kg/45D (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
Biochemical - Metabolism (Intermediary) - lipids including transport
|
SIMEJ* Singapore medical journal(Singapore, Singapore Medical Assn.) V.1- 1960- Volume(issue)/page/year: 48,311,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
13920 mg/kg/3D (intermittent)
|
Behavioral - alteration of classical conditioning
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 30,256,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
15000 mg/kg/3D (intermittent)
|
Brain and Coverings - changes in brain weight
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 30,228,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
21 gm/kg/3W (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 46,2658,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
1344 gm/kg/8W (intermittent)
|
Liver - hepatitis (hepatocellular necrosis), diffuse
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
Biochemical - Metabolism (Intermediary) - lipids including transport
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 252,64,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
665 mL/kg/6W (continuous)
|
Vascular - contraction (isolated tissues)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 153,468,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
665 mL/kg/6W (continuous)
|
Vascular - contraction (isolated tissues)
Vascular - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
|
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 153,468,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
324000 mg/kg/90D (intermittent)
|
Liver - fatty liver degeneration
Liver - other changes
Kidney/Ureter/Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
657000 mg/kg/90D (intermittent)
|
Cardiac - changes in heart weight
Liver - changes in liver weight
Kidney/Ureter/Bladder - changes in kidney weight
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
252000 mg/kg/90D (intermittent)
|
Endocrine - changes in thymus weight
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
2016 gm/kg/36W (intermittent)
|
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Primate - monkey
|
13500 gm/kg/72W (intermittent)
|
Liver - fatty liver degeneration
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
35 gm/kg/1W (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
25000 mg/m3/14D (intermittent)
|
Blood - changes in bone marrow (not otherwise specified)
Blood - changes in spleen
Blood - other changes
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - mouse
|
22000 mg/m3/20D (intermittent)
|
Blood - thrombocytopenia
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Unreported
|
Primate - monkey
|
261000 mg/kg/90D (intermittent)
|
Endocrine - changes in luteinizing hormone
Related to Chronic Data - changes in ovarian weight
Related to Chronic Data - changes in uterine weight
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
25200 mg/kg/7D (intermittent)
|
Related to Chronic Data - death
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Parenteral
|
Rodent - rat
|
336000 mg/kg/4W (intermittent)
|
Musculoskeletal - osteoporosis
Musculoskeletal - other changes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,193,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
540000 mg/kg/45D (intermittent)
|
Liver - other changes
Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,237,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
112000 mg/kg/4W (continuous)
|
Endocrine - other changes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,281,2009
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
13.2 gm/kg/6D (intermittent)
|
Brain and Coverings - other degenerative changes
|
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 30,459,2009
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
26.4 gm/kg/6D (intermittent)
|
Brain and Coverings - other degenerative changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 30,459,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
28000 mg/kg/7D (continuous)
|
Liver - other changes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,339,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
56000 mg/kg/7D (continuous)
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,339,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
963.2 gm/kg/16W (continuous)
|
Behavioral - food intake (animal)
Behavioral - fluid intake
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988 Volume(issue)/page/year: 22,65,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
25200 mg/kg/7D (intermittent)
|
Behavioral - food intake (animal)
Lungs, Thorax, or Respiration - respiratory depression
Related to Chronic Data - death
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
522 gm/kg/90D (intermittent)
|
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - fatty liver degeneration
Kidney/Ureter/Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
360 gm/kg/90D (intermittent)
|
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
1440 gm/kg/90D (intermittent)
|
Liver - changes in liver weight
Kidney/Ureter/Bladder - changes in kidney weight
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
300 gm/kg/12W (continuous)
|
Liver - other changes
Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation
Biochemical - Metabolism (Intermediary) - other proteins
|
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 180,31,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
336 gm/kg/12W (continuous)
|
Vascular - BP elevation not characterized in autonomic section
Vascular - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
|
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 26,427,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
56.25 gm/kg/90D (continuous)
|
Gastrointestinal - gastritis
Biochemical - Metabolism (Intermediary) - lipids including transport
Biochemical - Metabolism (Intermediary) - other proteins
|
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 28,591,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
672000 mg/kg/12W (continuous)
|
Brain and Coverings - other degenerative changes
Cardiac - changes in heart weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 187,149,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
175 mL/kg/10W (intermittent)
|
Brain and Coverings - other degenerative changes
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
Related to Chronic Data - changes in testicular weight
|
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004- Volume(issue)/page/year: 101,320,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
16000 mg/kg/8D (intermittent)
|
Behavioral - changes in motor activity (specific assay)
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 201,249,2008
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
48000 mg/kg/8D (intermittent)
|
Behavioral - somnolence (general depressed activity)
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 201,249,2008
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
22.4 gm/m3/5D (intermittent)
|
Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 193,495,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
14000 mg/kg/7D (intermittent)
|
Behavioral - changes in motor activity (specific assay)
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 197,361,2008
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
5400 mg/kg/2D (intermittent)
|
Behavioral - tolerance
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 194,139,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
8000 mg/kg/4D (intermittent)
|
Behavioral - changes in motor activity (specific assay)
Behavioral - alteration of classical conditioning
|
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 195,103,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
469 gm/kg/12W (intermittent)
|
Gastrointestinal - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
Biochemical - Metabolism (Intermediary) - other proteins
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 329,952,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
194 gm/kg/6W (continuous)
|
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 331,23,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
298 gm/kg/8W (continuous)
|
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 331,23,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
298 gm/kg/8W (continuous)
|
Behavioral - food intake (animal)
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 331,23,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
2070 gm/kg/0.5Y (continuous)
|
Liver - other changes
Endocrine - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 331,23,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
2070 gm/kg/0.5Y (continuous)
|
Liver - other changes
Endocrine - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphokinase
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 331,23,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
213.15 gm/kg/15D (continuous)
|
Behavioral - tremor
Behavioral - changes in motor activity (specific assay)
Behavioral - withdrawal
|
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: -,1,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
355.5 gm/kg/45D (intermittent)
|
Liver - hepatitis (hepatocellular necrosis), diffuse
Liver - liver function tests impaired
Kidney/Ureter/Bladder - renal function tests depressed
|
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 21,355,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
300 gm/kg/60D (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - peptidases
Biochemical - Metabolism (Intermediary) - other proteins
|
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 21,507,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
300 gm/kg/60D (intermittent)
|
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - lipids including transport
Biochemical - Metabolism (Intermediary) - effect on Sodium-Potassium pump
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 47,1958,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1512 gm/kg/90D (intermittent)
|
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Biochemical - Metabolism (Intermediary) - lipids including transport
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 47,2666,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
96 gm/kg/16D (intermittent)
|
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 31,303,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
42 gm/kg/7D (intermittent)
|
Behavioral - alteration of classical conditioning
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 32,158,2010
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
180 gm/kg/45D (intermittent)
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 32,164,2010
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
70 gm/kg/10W (intermittent)
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
Biochemical - Metabolism (Intermediary) - lipids including transport
Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
|
PAINDB Pain. (Elsevier North Holland, Netherlands) V.1- 1975- Volume(issue)/page/year: 145,129,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
355.5 gm/kg/45D (intermittent)
|
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - other
|
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 21,621,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
40 gm/kg/8D (intermittent)
|
Liver - liver function tests impaired
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 48,1632,2010
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
355.5 gm/kg/9W (intermittent)
|
Liver - other changes
Biochemical - Metabolism (Intermediary) - other proteins
Biochemical - Metabolism (Intermediary) - effect on mitochondrial function
|
FTRPAE Fitoterapia. (Inverni della Beffa SpA, via Ripamonti, 99, 20141 Milan, Italy) V.18- 1947- Volume(issue)/page/year: 81,1239,2010
|
|
TDLo - Lowest published toxic dose
|
Unreported
|
Rodent - rat
|
20 gm/kg/10D (intermittent)
|
Behavioral - alteration of classical conditioning
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 32,503,2010
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
16 gm/kg/5D (intermittent)
|
Liver - hepatitis (hepatocellular necrosis), zonal
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
Biochemical - Metabolism (Intermediary) - lipids including transport
|
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 47,730,2009
|
|
| Type of Test |
Route of Exposure or Administration |
Species/Test System |
Dose Data |
Toxic Effects |
Reference |
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
320 mg/kg/50W (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Blood - lymphoma, including Hodgkin's disease
|
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 13,345,1981
|
|
TDLo - Lowest published toxic dose
|
Rectal
|
Rodent - mouse
|
120 gm/kg/18W (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
|
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie. (Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see ZIEKBA. Volume(issue)/page/year: 59,203,1928
|
|
TD - Toxic dose (other than lowest)
|
Oral
|
Rodent - mouse
|
400 gm/kg/57W (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
|
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie. (Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see ZIEKBA. Volume(issue)/page/year: 59,203,1928
|
|
| Type of Test |
Route of Exposure or Administration |
Species/Test System |
Dose Data |
Sex/Duration |
Toxic Effects |
Reference |
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - woman
|
41 gm/kg
|
female 41 week(s) after conception
|
Reproductive - Effects on Newborn - Apgar score (human only)
Reproductive - Effects on Newborn - other neonatal measures or effects
Reproductive - Effects on Newborn - drug dependence
|
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 129,1075,1975
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - woman
|
250 mg/kg
|
female 37 week(s) after conception
|
Reproductive - Effects on Embryo or Fetus - other effects to embryo
|
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 145,251,1983
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Human - woman
|
8 gm/kg
|
female 32 week(s) after conception
|
Reproductive - Effects on Newborn - Apgar score (human only)
Reproductive - Effects on Newborn - other neonatal measures or effects
|
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 134,419,1980
|
|
TDLo - Lowest published toxic dose
|
Intrauterine
|
Human - woman
|
200 mg/kg
|
female 5 day(s) pre-mating
|
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
|
INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 14,280,1969
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
78 gm/kg
|
female 7-19 day(s) after conception
|
Reproductive - Effects on Newborn - biochemical and metabolic
|
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- Volume(issue)/page/year: 59,577,1998
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
4 gm/kg
|
female 13 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
|
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 15(2),23,1981
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
322 gm/kg
|
male 35 day(s) pre-mating
|
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
|
INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 23,176,1978
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
12 gm/kg
|
female 9-12 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
PLPSAX Physiological Psychology. (Austin, TX) V.1-14, 1973-86. Volume(issue)/page/year: 7,311,1979
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
132 gm/kg
|
female 1-22 day(s) after conception
|
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Reproductive - Effects on Newborn - behavioral
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 23,217,1981
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
24 gm/kg
|
female 14-16 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 23,41A,1981
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
354 gm/kg
|
lactating female 10 day(s) post-birth
|
Reproductive - Effects on Newborn - biochemical and metabolic
|
RCPBDC Research Communications in Psychology, Psychiatry and Behavior. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1976- Volume(issue)/page/year: 2,119,1977
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
4 gm/kg
|
female 6-15 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - urogenital system
|
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 10,267,1982
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
35295 mg/kg
|
female 1-15 day(s) after conception
|
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
|
ONGZAC Ontogenez (Moscow). For English translation, see SJDBA9. (V/O Mezhdunarodnaya Kniga, 113095, Moscow, USSR) V.1- 1970- Volume(issue)/page/year: 22(1),71,1991
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
44 gm/kg
|
female 7-17 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - urogenital system
|
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (103),10,1985
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
20000 ppm/7H
|
female 1-22 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 29(2),48A,1984
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
15 gm/kg
|
female 8-13 day(s) after conception
|
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - physical
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 36,31A,1987
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
2240 mg/kg
|
female 9-12 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
|
DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 38,5835,1978
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
600 mg/kg
|
female 8-15 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26(1),12A,1982
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
600 mg/kg
|
female 8-15 day(s) after conception
|
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 21,108,1983
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
600 mg/kg
|
female 8-15 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
|
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 21,108,1983
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
3600 mg/kg
|
female 7-8 day(s) after conception
|
Reproductive - Effects on Newborn - behavioral
|
NELED5 Neuroscience Letters. (Elsevier Scientific Publishers Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 289,13,2000
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - rat
|
4 gm/kg
|
female 6-7 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
|
RECYAR Revue Roumaine d'Embryologie et de Cytologia, Serie d'Embrologie. (Bucharest, Romania) V.1-8, 1964-71. Volume(issue)/page/year: 8,105,1971
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - rat
|
3 gm/kg
|
female 6-7 day(s) after conception
|
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
|
RECYAR Revue Roumaine d'Embryologie et de Cytologia, Serie d'Embrologie. (Bucharest, Romania) V.1-8, 1964-71. Volume(issue)/page/year: 8,105,1971
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - rat
|
4 gm/kg
|
female 6-7 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
|
RECYAR Revue Roumaine d'Embryologie et de Cytologia, Serie d'Embrologie. (Bucharest, Romania) V.1-8, 1964-71. Volume(issue)/page/year: 8,105,1971
|
|
TDLo - Lowest published toxic dose
|
Intracerebral
|
Rodent - rat
|
5 mg/kg
|
female 1 day(s) pre-mating
|
Reproductive - Fertility - other measures of fertility
|
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 42,199,1975
|
|
TDLo - Lowest published toxic dose
|
Unreported
|
Rodent - rat
|
60 gm/kg
|
female 9-14 day(s) after conception
|
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 45(1),83,1982
|
|
TDLo - Lowest published toxic dose
|
Intratesticular
|
Rodent - rat
|
400 mg/kg
|
male 1 day(s) pre-mating
|
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
|
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 24,884,1973
|
|
TDLo - Lowest published toxic dose
|
Intrauterine
|
Rodent - rat
|
2400 mg/kg
|
female 10 day(s) after conception
|
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
|
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 14,316,1976
|
|
TDLo - Lowest published toxic dose
|
Multiple routes
|
Rodent - rat
|
642 gm/kg
|
female 1-21 day(s) after conception
lactating female 23 day(s) post-birth
|
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
DEPBA5 Developmental Psychobiology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1968- Volume(issue)/page/year: 10,435,1977
|
|
TDLo - Lowest published toxic dose
|
Multiple routes
|
Rodent - rat
|
373 gm/kg
|
lactating female 23 day(s) post-birth
|
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - physical
|
DEPBA5 Developmental Psychobiology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1968- Volume(issue)/page/year: 10,435,1977
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
162 gm/kg
|
female 11-19 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 27,56A,1983
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
21 gm/kg
|
female 1-21 day(s) after conception
|
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - behavioral
|
JSALDP Journal of Studies on Alcohol. (P.O. Box 969, Piscataway, NJ 08854) V.36- 1975- Volume(issue)/page/year: 38,1696,1977
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
5800 mg/kg
|
female 7 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 27,231,1983
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
75600 mg/kg
|
female 5-11 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - urogenital system
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 23,127,1979
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
5500 mg/kg
|
female 9 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 24(1),53A,1981
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
1680 gm/kg
|
male 70 day(s) pre-mating
|
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
|
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 39,542,1980
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
5800 mg/kg
|
female 10 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 27,231,1983
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
5800 mg/kg
|
female 7 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 27,231,1983
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
5622 ug/kg
|
female 10 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
|
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 124,676,1976
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
4 mg/kg
|
female 10 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
|
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 193,515,1979
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
4300 mg/kg
|
female 10 day(s) after conception
|
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
|
NETOD7 Neurobehavioral Toxicology. (Fayetteville, NY) V.1-2, 1979-80. For publisher information, see NTOTDY. Volume(issue)/page/year: 2,227,1980
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Mammal - dog
|
21600 mg/kg
|
female 1-60 day(s) after conception
|
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 36,285,1977
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Mammal - dog
|
260 gm/kg
|
female 1-62 day(s) after conception
|
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
|
ACRSDM Alcoholism: Clinical and Experimental Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1977- Volume(issue)/page/year: 4,123,1980
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Mammal - dog
|
221 gm/kg
|
female 1-47 day(s) after conception
|
Reproductive - Fertility - abortion
|
ACRSDM Alcoholism: Clinical and Experimental Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1977- Volume(issue)/page/year: 4,123,1980
|
|
TDLo - Lowest published toxic dose
|
Intratesticular
|
Mammal - dog
|
100 mg/kg
|
male 1 day(s) pre-mating
|
Reproductive - Paternal Effects - testes, epididymis, sperm duct
|
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 24,884,1973
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Primate - monkey
|
78 gm/kg
|
female 4-23 week(s) after conception
|
Reproductive - Fertility - abortion
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,345,1987
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Primate - monkey
|
400 mg/kg
|
female 2-21 week(s) after conception
|
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 29,49,1984
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Primate - monkey
|
206 gm/kg
|
female 90 day(s) pre-mating
|
Reproductive - Maternal Effects - menstrual cycle changes or disorders
|
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 221,677,1983
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Primate - monkey
|
32400 mg/kg
|
female 2-19 week(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,29,1991
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Primate - monkey
|
43200 mg/kg
|
female 1-24 week(s) after conception
|
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,29,1991
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rabbit
|
3945 mg/kg
|
female 1 day(s) pre-mating
|
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
|
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 34,275,1966
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rabbit
|
3750 mg/kg
|
female 1 day(s) pre-mating
|
Reproductive - Fertility - other measures of fertility
|
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 58,501,1970
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - rabbit
|
15 mg/kg
|
female 15-29 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - other effects to embryo
|
JPDSA3 Journal of Pediatric Surgery. (Grune and Stratton, Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1966- Volume(issue)/page/year: 29,1030,1994
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Mammal - pig
|
2648 gm/kg
|
female 78 week(s) pre-mating
1-16 week(s) after conception
|
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 5,229,1983
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
90 gm/kg
|
female 1-68 day(s) after conception
|
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Reproductive - Effects on Newborn - behavioral
|
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 127,438,1957
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
240 gm/kg
|
female 2-61 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
|
DBRRDB Developmental Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1981- Volume(issue)/page/year: 106,39,1998
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
264 gm/kg
|
female 2-67 day(s) after conception
|
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - physical
|
ACRSDM Alcoholism: Clinical and Experimental Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1977- Volume(issue)/page/year: 23,1816,1999
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
72 gm/kg
|
female 45-62 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
|
FAJOEC FASEB Journal. Official Publication of the Federation of American Societies for Experimental Biology. (Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1987- Volume(issue)/page/year: 14,A1447,2000
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Mammal - domestic
|
94 gm/kg
|
female 14-21 week(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- Volume(issue)/page/year: 12,329,1980
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Mammal - domestic
|
40 gm/kg
|
female 14-17 week(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Effects on Newborn - biochemical and metabolic
|
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 3,105,1981
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Mammal - domestic
|
1 gm/kg
|
female 18 week(s) after conception
|
Reproductive - Specific Developmental Abnormalities - respiratory system
|
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 151,859,1985
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Mammal - species unspecified
|
31500 mg/kg
|
female 15-35 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 30,203,1984
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
76000 mg/kg
|
female 43-62 day(s) after conception
|
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Newborn - other neonatal measures or effects
Reproductive - Effects on Embryo or Fetus - other effects to embryo
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 23,355,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
191220 mg/kg
|
female 2-20 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - other postnatal measures or effects
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 23,453,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
264000 mg/kg
|
female 2-67 day(s) after conception
|
Reproductive - Maternal Effects - other effects
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - physical
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 22,183,2000
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Mammal - domestic
|
29000 mg/kg
|
female 106-134 day(s) after conception
|
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Newborn - other neonatal measures or effects
Reproductive - Effects on Newborn - behavioral
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 22,205,2000
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
30 gm/kg
|
female 1-20 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - other neonatal measures or effects
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 163,15,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
20 gm/kg
|
multigenerations
|
Reproductive - Specific Developmental Abnormalities - hepatobiliary system
Reproductive - Specific Developmental Abnormalities - urogenital system
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: #PB85118651
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
20 gm/kg
|
multigenerations
|
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: #PB85118651
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
20 gm/kg
|
multigenerations
|
Reproductive - Specific Developmental Abnormalities - urogenital system
|
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: #PB85118651
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
22.5 gm/kg
|
female 11-20 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - other postnatal measures or effects
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 24,719,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
40 gm/kg
|
female 1-20 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
Reproductive - Specific Developmental Abnormalities - Central Nervous System
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 45,68,1982
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
42 gm/kg
|
female 1-21 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 45,66,1982
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
700 gm/kg
|
male 7 day(s) pre-mating
female 7 day(s) pre-mating
21 day(s) after conception
|
Reproductive - Effects on Newborn - live birth index (measured after birth)
|
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: #PB85118651
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
240 gm/kg
|
male 30 day(s) pre-mating
|
Reproductive - Specific Developmental Abnormalities - urogenital system
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 47,82,1984
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
65 gm/kg
|
female 7-19 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - endocrine system
|
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 138,389,1997
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
75 gm/kg
|
female 7-21 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - endocrine system
|
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 138,389,1997
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
112 mg/kg
|
male 14 day(s) pre-mating
|
Reproductive - Effects on Newborn - biochemical and metabolic
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 48,86,1985
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
147 mg/kg
|
female 1-21 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - endocrine system
Reproductive - Effects on Newborn - delayed effects
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 47,84,1984
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
60000 mg/kg
|
lactating female 1-30 day(s) post-birth
|
Reproductive - Specific Developmental Abnormalities - endocrine system
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - delayed effects
|
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 48,93,1985
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
900 mL/kg
|
female 19 day(s) pre-mating - 21 day(s) post-birth
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Reproductive - Effects on Newborn - biochemical and metabolic
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 24,275,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
110 gm/kg
|
female 1-23 day(s) after conception
|
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - physical
|
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 59,44,1996
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
135 gm/kg
|
female 1 day(s) after conception - 7 day(s) post-birth
|
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - physical
|
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 59,44,1996
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
2.9 gm/kg
|
female 8 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,171,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
210 gm/kg
|
female 6-20 day(s) after conception
|
Reproductive - Fertility - abortion
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72(Suppl 1),341,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
11.25 mg/kg
|
female 7-9 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 17,475,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
15 mg/kg
|
female 6-8 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 17,475,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
90 mg/kg
|
male 30 day(s) pre-mating
|
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
Reproductive - Paternal Effects - other effects on male
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
|
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 71,3059,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
264 gm/kg
|
female 2-67 day(s) after conception
|
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - other postnatal measures or effects
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 25,59,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
30 gm/kg
|
female 16-20 day(s) after conception
|
Reproductive - Effects on Newborn - other postnatal measures or effects
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 25,447,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
120 gm/kg
|
female 1-20 day(s) after conception
|
Reproductive - Effects on Newborn - other postnatal measures or effects
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 25,447,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
272 gm/kg
|
female 2-67 day(s) after conception
|
Reproductive - Effects on Newborn - other postnatal measures or effects
Reproductive - Effects on Newborn - delayed effects
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 26,59,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
57 gm/kg
|
female 43-62 day(s) after conception
|
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 26,543,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
45 gm/kg
|
female 15-22 day(s) after conception
lactating female 7 day(s) post-birth
|
Reproductive - Effects on Newborn - behavioral
|
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 24,691,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
45 gm/kg
|
female 15-22 day(s) after conception
lactating female 7 day(s) post-birth
|
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - other postnatal measures or effects
|
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 26,191,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
10400 mg/kg
|
female 7-19 day(s) after conception
|
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Reproductive - Effects on Newborn - delayed effects
|
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 90,2225,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
110 gm/kg
|
female 10-20 day(s) after conception
|
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - biochemical and metabolic
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 27,73,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
120 gm/kg
|
female 6-15 day(s) after conception
|
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,57,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
16.25 gm/kg
|
female 7-19 day(s) after conception
|
Reproductive - Maternal Effects - other effects
Reproductive - Tumorigenic effects - other reproductive system tumors
Reproductive - Effects on Newborn - biochemical and metabolic
|
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 90,2225,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
54 gm/kg
|
female 6-14 day(s) after conception
|
Reproductive - Maternal Effects - other effects
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,280,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
22.8 gm/kg
|
female 6-8 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 20,453,2005
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
22.8 gm/kg
|
female 6-8 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Specific Developmental Abnormalities - eye/ear
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 20,453,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
60 gm/kg
|
female 6-15 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 577S,1,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
36.5 gm/kg
|
female 30 day(s) pre-mating - 21 day(s) post-birth
|
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
Reproductive - Effects on Newborn - behavioral
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 27,585,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
292 gm/kg
|
female 30 day(s) pre-mating - 21 day(s) post-birth
|
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - behavioral
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 27,585,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
204 gm/kg
|
female 0-67 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - behavioral
|
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 308,650,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
50 gm/kg
|
female 6-15 day(s) after conception
|
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 22,61,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
50 gm/kg
|
female 6-15 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 22,61,2006
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
22.8 gm/kg
|
female 6-8 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 22,263,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
94500 mg/kg
|
female 1-21 day(s) after conception
|
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Reproductive - Effects on Newborn - behavioral
|
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
94500 mg/kg
|
female 1-21 day(s) after conception
|
Reproductive - Effects on Newborn - physical
Reproductive - Effects on Newborn - other postnatal measures or effects
|
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Human - woman
|
5860 mL/kg
|
female 3 year(s) pre-mating - 100 day(s) post-birth
|
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - delayed effects
|
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)- Volume(issue)/page/year: 37,129,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
99000 mg/kg
|
multigenerations
|
Reproductive - Effects on Newborn - biochemical and metabolic
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 28,238,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
264 gm/kg
|
female 2-67 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Effects on Newborn - behavioral
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 28,333,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1188 gm/kg
|
male 55 day(s) pre-mating
|
Reproductive - Paternal Effects - impotence
Reproductive - Paternal Effects - other effects on male
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 22,599,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1188 gm/kg
|
male 55 day(s) pre-mating
|
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 22,599,2006
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
5.8 gm/kg
|
female 3-5 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
|
BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003- Volume(issue)/page/year: 70,163,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
22.8 gm/kg
|
female 6-8 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
|
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998- Volume(issue)/page/year: 67,2073,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
21 gm/kg
|
female 8-14 day(s) after conception
|
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - other postnatal measures or effects
Reproductive - Effects on Newborn - delayed effects
|
ALCOH* Alcohol (Fayetteville, N.Y., New York Ny : Elsevier Science) V.1- 1984- Volume(issue)/page/year: 6,353,1989
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
260 gm/kg
|
female 2-67 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - behavioral
|
ALCOH* Alcohol (Fayetteville, N.Y., New York Ny : Elsevier Science) V.1- 1984- Volume(issue)/page/year: 41,577,2007
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
360 gm/kg
|
male 60 day(s) pre-mating
female 60 day(s) pre-mating
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
BDERB* Birth defects research. Part B, Developmental and reproductive toxicology (Hoboken, N.J. : Wiley-Liss) V.68- 2003- Volume(issue)/page/year: 71,135,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
180 gm/kg
|
female 60 day(s) pre-mating
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
BDERB* Birth defects research. Part B, Developmental and reproductive toxicology (Hoboken, N.J. : Wiley-Liss) V.68- 2003- Volume(issue)/page/year: 71,135,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
3270 gm/kg
|
female 13 week(s) pre-mating - 3 week(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003- Volume(issue)/page/year: 73,980,2005
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
18000 mg/kg
|
female 5-21 day(s) after conception
|
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Reproductive - Effects on Newborn - other postnatal measures or effects
|
BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003- Volume(issue)/page/year: 73,897,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
3210 gm/kg
|
female 13 week(s) pre-mating - 16 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003- Volume(issue)/page/year: 73,65,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
2900 mg/kg
|
female 8 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
TERMG* Teratology Society. Platform Sessions Abstracts. Concurrent Platform Session III. Mechanism Genomics RA Volume(issue)/page/year: -,234,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
2900 mg/kg
|
female 8 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
TERP2* Teratology Society. Poster Session Abstracts. Joint TS/NBTS Poster Session II Volume(issue)/page/year: -,368,2005
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
2900 mg/kg
|
female 8 day(s) after conception
|
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
|
TERST* Teratology Society. Platform Sessions Abstracts. Student Plenary Session Volume(issue)/page/year: -,315,2006
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
2900 mg/kg
|
female 8 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
TERST* Teratology Society. Platform Sessions Abstracts. Student Plenary Session Volume(issue)/page/year: -,315,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
378 gm/kg
|
male 9 week(s) pre-mating
|
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
252 gm/kg
|
female 12 day(s) after conception - 10 day(s) post-birth
|
Reproductive - Effects on Newborn - other neonatal measures or effects
Reproductive - Effects on Newborn - delayed effects
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
20000 ppm
|
female 1-19 day(s) after conception
|
Reproductive - Maternal Effects - other effects
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
43 gm/kg
|
female 1 day(s) after conception - 21 day(s) post-birth
|
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
175000 mg/kg
|
female 28 day(s) pre-mating - 22 day(s) after conception
|
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Reproductive - Effects on Newborn - behavioral
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
182250 mg/kg
|
female 6-20 day(s) after conception
|
Reproductive - Effects on Newborn - behavioral
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
273 gm/kg
|
female 21 day(s) after conception - 21 day(s) post-birth
|
Reproductive - Effects on Newborn - behavioral
|
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 30,23,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
2398 mL/kg
|
female 60 day(s) pre-mating
3 week(s) after conception
lactating female 4 week(s) post-birth
|
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - behavioral
|
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 30,59,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
150 gm/kg
|
female 4-9 day(s) after conception
|
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
20000 ppm
|
female 1-19 day(s) after conception
|
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
868 gm/kg
|
male 28 day(s) pre-mating
|
Reproductive - Paternal Effects - other effects on male
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
25200 mg/kg
|
female 8-14 day(s) after conception
|
Reproductive - Maternal Effects - other effects
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
35000 mg/kg
|
female 8-14 day(s) after conception
|
Reproductive - Maternal Effects - other effects
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
Reproductive - Effects on Newborn - live birth index (measured after birth)
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
2173.5 gm/kg
|
multigenerations
|
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Effects on Newborn - live birth index (measured after birth)
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
1053.5 gm/kg
|
male 49 day(s) pre-mating
|
Reproductive - Paternal Effects - other effects on male
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
784 gm/kg
|
female 56 day(s) pre-mating
|
Reproductive - Maternal Effects - other effects
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
30 mg/kg
|
female 7 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
|
BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003- Volume(issue)/page/year: 79,513,2007
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
18 gm/kg
|
female 5-22 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
|
BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003- Volume(issue)/page/year: 85,791,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
96 gm/kg
|
female 5-20 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Reproductive - Effects on Newborn - behavioral
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 31,303,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
96 gm/kg
|
female 5-20 day(s) after conception
|
Reproductive - Effects on Newborn - physical
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 31,303,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - guinea pig
|
260 gm/kg
|
female 1-65 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - hepatobiliary system
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 32,164,2010
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
126 gm/kg
|
lactating female 21 day(s) post-birth
|
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - other postnatal measures or effects
Reproductive - Effects on Newborn - delayed effects
|
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 23(Suppl 1),16,2009
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1680 gm/kg
|
female 8 week(s) pre-mating - 7 day(s) post-birth
|
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 48,3486,2010
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1960 gm/kg
|
female 8 week(s) pre-mating - 21 day(s) post-birth
|
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 48,3486,2010
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
5.8 gm/kg
|
female 7 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
|
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 33,231,2011
|
|
| Type of Test |
Route of Exposure or Administration |
Species/Test System |
Dose Data |
Reference |
|
Mutation in microorganisms
|
|
Bacteria - Salmonella typhimurium
|
11 pph
|
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 52,225,1990
|
|
Mutation in microorganisms
|
|
Bacteria - Escherichia coli
|
140 gm/L
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 130,97,1984
|
|
DNA repair
|
|
Bacteria - Escherichia coli
|
5 mg/well
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984
|
|
Sex chromosome loss and nondisjunction
|
Oral
|
Insect - Drosophila melanogaster
|
10 pph
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,95,1992
|
|
Mutation in microorganisms
|
|
Yeast - Saccharomyces cerevisiae
|
24 pph
|
GNKAA5 Genetika (Moscow). For English translation, see SOGEBZ. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1965- Volume(issue)/page/year: 15,927,1979
|
|
DNA damage
|
|
Yeast - Saccharomyces cerevisiae
|
850 mmol/L
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 326,165,1995
|
|
Mutation in microorganisms
|
|
Mold - Aspergillus nidulans
|
20 pph
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,51,1977
|
|
Gene conversion and mitotic recombination
|
|
Mold - Aspergillus nidulans
|
5 pph
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,51,1977
|
|
Sex chromosome loss and nondisjunction
|
|
Mold - Aspergillus nidulans
|
30 gm/L
|
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 31,81,1979
|
|
Cytogenetic analysis
|
Parenteral
|
Insect - grasshopper
|
500 mmol/L
|
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year: 51,646,1964
|
|
DNA inhibition
|
|
Human
Lymphocyte
|
220 mmol/L
|
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,1171,1982
|
|
Cytogenetic analysis
|
|
Human
Lymphocyte
|
1160 gm/L
|
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year: 85A,25,1977
|
|
Cytogenetic analysis
|
|
Human
Fibroblast
|
12000 ppm
|
ACYTAN Acta Cytologica. (Science Printers and Pub., Inc., 2 Jacklynn Ct., St. Louis, MO 63132) V.1- 1957- Volume(issue)/page/year: 16,41,1972
|
|
Cytogenetic analysis
|
|
Human
Leukocyte
|
1 pph/72H (continuous)
|
TSITAQ Tsitologiya. Cytology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1959- Volume(issue)/page/year: 20,421,1978
|
|
Sister chromatid exchange
|
|
Human
Lymphocyte
|
500 ppm/72H (continuous)
|
CGCGBR Cytogenetics and Cell Genetics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.12- 1973- Volume(issue)/page/year: 27,66,1980
|
|
DNA damage
|
Oral
|
Rodent - rat
|
4 gm/kg
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 345,191,1995
|
|
Mutation test systems - not otherwise specified
|
Intraperitoneal
|
Rodent - rat
|
250 gm/kg/16D (continuous)
|
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 56,195,1988
|
|
Mutation test systems - not otherwise specified
|
Oral
|
Rodent - rat
|
3 gm/kg
|
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 49,125,1981
|
|
Cytogenetic analysis
|
Oral
|
Rodent - rat
|
2 gm/kg
|
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 14(5),48,1980
|
|
Micronucleus test
|
Intraperitoneal
|
Rodent - mouse
|
1240 mg/kg/2D
|
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year: 85A,25,1977
|
|
Cytogenetic analysis
|
Oral
|
Rodent - mouse
|
40 gm/kg
|
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 302,258,1983
|
|
Sister chromatid exchange
|
Oral
|
Rodent - mouse
|
420 mg/kg/3W
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,291,1979
|
|
Sex chromosome loss and nondisjunction
|
Oral
|
Rodent - mouse
|
5 gm/kg
|
CGCGBR Cytogenetics and Cell Genetics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.12- 1973- Volume(issue)/page/year: 44,7,1987
|
|
Dominant lethal test
|
Oral
|
Rodent - mouse
|
3720 mg/kg/3D
|
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year: 85A,25,1977
|
|
Sperm Morphology
|
Oral
|
Rodent - mouse
|
1500 mg/kg/50D
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 65,229,1979
|
|
Cytogenetic analysis
|
|
Rodent - hamster
Ovary
|
100 ppm
|
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl 6),72,1986
|
|
Cytogenetic analysis
|
|
Rodent - hamster
Embryo
|
1 pph
|
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,207,1988
|
|
Cytogenetic analysis
|
|
Rodent - hamster
Ovary
|
160 mmol/L
|
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881- Volume(issue)/page/year: 106,169,1987
|
|
Sister chromatid exchange
|
|
Rodent - hamster
Ovary
|
3900 mg/L
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,85,1983
|
|
Micronucleus test
|
|
Mammal - dog
Lymphocyte
|
400 umol/L
|
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A075-605
|
|
DNA adduct
|
Oral
|
Rodent - rat
|
5 gm/kg
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 479,81,2001
|
|
DNA adduct
|
Oral
|
Rodent - rat
|
3 gm/kg/7D
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 479,81,2001
|
|
Cytogenetic analysis
|
|
Human
Lymphocyte
|
2.5 pph/24H
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 537,117,2003
|
|
Micronucleus test
|
Intramuscular
|
Fish - not otherwise specified
|
1 pph
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 542,1,2003
|
|
Cytogenetic analysis
|
Intramuscular
|
Fish - not otherwise specified
|
1 pph
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 542,1,2003
|
|
Cytogenetic analysis
|
Oral
|
Human
|
49014 gm/kg/25Y
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 560,187,2004
|
|
Micronucleus test
|
|
Human
Liver
|
15 mmol/L/24H
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 198,315,2004
|
|
DNA damage
|
|
Bacteria - Salmonella typhimurium
|
15 pph/120M
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 575,34,2005
|
|
DNA repair
|
|
Bacteria - Salmonella typhimurium
|
15 pph/120M
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 575,34,2005
|
|
Specific locus test
|
Oral
|
Rodent - rat
|
56 gm/kg/4W
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 577S,1,2005
|
|
Micronucleus test
|
Oral
|
Human
|
817.6 gm/kg/6Y (intermittent)
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 615,134,2007
|
|
DNA damage
|
Oral
|
Rodent - rat
|
3150 gm/kg/1Y (intermittent)
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 254,11,2008
|
|
Cytogenetic analysis
|
Oral
|
Rodent - rat
|
504 gm/kg/6W (intermittent)
|
HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
|
|
Micronucleus test
|
|
Human
Cells - not otherwise specified
|
4 gm/L
|
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 17,509,2002
|
|
Sister chromatid exchange
|
|
Rodent - hamster
Ovary
|
31.6 gm/L/1H
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
Sister chromatid exchange
|
|
Human
Lymphocyte
|
0.5 gm/L/72H
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
Sister chromatid exchange
|
|
Human
Lymphocyte
|
10 gm/L/24H
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
Sister chromatid exchange
|
Intraperitoneal
|
Rodent - mouse
|
0.6 mg/kg
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
Sister chromatid exchange
|
Oral
|
Rodent - mouse
|
2800 gm/kg/10W (intermittent)
|
HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
|
|
Gene conversion and mitotic recombination
|
|
Insect - Drosophila melanogaster
Cells - not otherwise specified
|
8.4 pph
|
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 48,644,2007
|
|
DNA damage
|
|
Human
Lymphocyte
|
100 mmol/L/3H
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 721,171,2011
|
|
|
|
|
ACGIH TLV-STEL 1000 ppm
|
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,2010
|
|
ACGIH TLV-Confirmed animal carcinogen
|
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,2010
|
|
IARC Cancer Review:Animal Inadequate Evidence
|
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 44,35,1988
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|
TOXICOLOGY REVIEW
|
IRXPAT International Review of Experimental Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962- Volume(issue)/page/year: 11,177,1972
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|
TOXICOLOGY REVIEW
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AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year: 56,291,1975
|
|
TOXICOLOGY REVIEW
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AICMA2 Archivos del Instituto de Cardiologia de Mexico. (Instituto de Cardiologia de Mexico, Juan Badiano No.1, 14080 Mexico City, Mexico) V.14- 1944- Volume(issue)/page/year: 44,874,1974
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TOXICOLOGY REVIEW
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MAEPBU Methods and Achievements in Experimental Pathology. (S. Karger AG, Postfach, CH-4009, Basel, Switzerland) V.1- 1966- Volume(issue)/page/year: 6,81,1972
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TOXICOLOGY REVIEW
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FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,433,1970
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CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973
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TOXICOLOGY REVIEW
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TOXICOLOGY REVIEW
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FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973
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TOXICOLOGY REVIEW
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TOXICOLOGY REVIEW
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TOXICOLOGY REVIEW
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TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979- Volume(issue)/page/year: 24,151,2003
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EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 45,271,2005
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| U.S. STANDARDS AND REGULATIONS |
- EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
- FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989
- EPA FIFRA 1998 STATUS OF PESTICIDES: RED Completed
- RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998 Volume(issue)/page/year: -,290,1998
- MSHA STANDARD-air:TWA 1000 ppm (1900 mg/m3)
- DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,103,1971
- OSHA PEL (Gen Indu):8H TWA 1000 ppm (1900 mg/m3)
- CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994
- OSHA PEL (Construc):8H TWA 1000 ppm (1900 mg/m3)
- CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994
- OSHA PEL (Shipyard):8H TWA 1000 ppm (1900 mg/m3)
- CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993
- OSHA PEL (Fed Cont):8H TWA 1000 ppm (1900 mg/m3)
- CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994
|
| OCCUPATIONAL EXPOSURE LIMITS |
- OEL-AUSTRALIA: TWA 1000 ppm (1880 mg/m3), JUL2008
- OEL-AUSTRIA: MAK-TMW 1000 ppm (1900 mg/m3);KZW 2000 ppm (3800 mg/m3), 2007
- OEL-BELGIUM: TWA 1000 ppm (1907 mg/m3), MAR2002
- OEL-DENMARK: TWA 1000 ppm (1900 mg/m3), MAY2011
- OEL-FINLAND: TWA 1000 ppm (1900 mg/m3), STEL 1300 ppm (2500 mg/m3), NOV2011
- OEL-FRANCE: VME 1000 ppm (1900 mg/m3), VLE 5000 ppm (9500), FEB2006
- OEL-GERMANY: MAK 960 mg/m3 (500 mL/m3), 2005
- OEL-HUNGARY: TWA 1900 mg/m3, STEL 7600 mg/m3, SEP2000
- OEL-ICELAND: TWA 1000 ppm (1900 mg/m3), NOV2011
- OEL-KOREA: TWA 1000 ppm (1900 mg/m3), 2006
- OEL-MEXICO: TWA 1000 ppm (1900 mg/m3), 2004
- OEL-THE NETHERLANDS: MAC-TGG 1000 mg/m3, 2003
- OEL-NEW ZEALAND: TWA 1000 ppm (1880 mg/m3), JAN2002
- OEL-NORWAY: TWA 500 ppm (950 mg/m3), JAN1999
- OEL-PERU: TWA 1000 ppm (1884 mg/m3), JUL2005
- OEL-THE PHILIPPINES: TWA 1000 ppm (1900 mg/m3), JAN1993
- OEL-POLAND: MAC(TWA) 1000 mg/m3, MAC(STEL) 3000 mg/m3, JAN1999
- OEL-RUSSIA: TWA 1000 mg/m3, STEL 2000 mg/m3, JUN2003
- OEL-SWEDEN: TWA 500 ppm (1000 mg/m3);STEL 1000 ppm (1900 mg/m3), JUN2005
- OEL-SWITZERLAND: MAK-W 500 ppm (960 mg/m3),KZG-W 1000 ppm (1920 mg/m3), DEC2006
- OEL-THAILAND: TWA 1000 ppm (1900 mg/m3), JAN1993
- OEL-TURKEY: TWA 1000 ppm (1900 mg/m3), JAN1993
- OEL-UNITED KINGDOM: TWA 1000 ppm (1920 mg/m3), OCT2007
- OEL IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
- OEL IN SINGAPORE, VIETNAM check ACGIH TLV
|
| NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA |
- NIOSH Recommended Exposure Level (Rel)
- NIOSH REL TO ETHYL ALCOHOL-air:10H TWA 1000 ppm
- Reference
- NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
- NIOSH Occupational Exposure Survey Data
- NOHS - National Occupational Hazard Survey (1974)
Hazard code: 31500
No. of industries: 430
No. of facilities: 157709 (estimated)
No. of occupations: 242
No. of employees: 2088926 (estimated)
NOES - National Occupational Exposure Survey (1983)
Hazard code: 31500
No. of industries: 334
No. of facilities: 86077 (estimated)
No. of occupations: 222
No. of employees: 2069125 (estimated)
No. of female employees: 1014002 (estimated)
|
- EPA GENETOX PROGRAM 1988, Positive: Rodent dominant lethal
- EPA GENETOX PROGRAM 1988, Negative: Aspergillus-forward mutation; SHE-clonal assay
- EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
- EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman; Mammalian micronucleus
- EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Histidine reversion-Ames test
- EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-human lymphocytes; In vitro SCE-human
- EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman; Sperm morphology-mouse
- EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
- EPA TSCA Section 8(b) CHEMICAL INVENTORY
- EPA TSCA Section 8(d) unpublished health/safety studies
- EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
- NIOSH Analytical Method, 1994: Ethanol in blood, 8002
- NIOSH Analytical Method, 1994: Alcohols I, 1400
- NTP Carcinogenesis studies; on test (two year studies), October 2000
- OSHA ANALYTICAL METHOD #100
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- RTECS® is provided quarterly by Accelrys, Inc., and was last updated: April, 2012.
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©2012 Canadian Centre for Occupational Health & Safety 